Calcium imaging of sleep-wake related neuronal activity in the dorsal pons

被引：86

作者：

Cox, Julia ^{[1
,2
]}

Pinto, Lucas ^{[1
,2
]}

Dan, Yang ^{[1
]}

机构：

[1] Univ Calif Berkeley, Howard Hughes Med Inst, Helen Wills Neurosci Inst, Div Neurobiol,Dept Mol & Cell Biol, 230 Li Ka Shing Ctr, Berkeley, CA 94720 USA

[2] Princeton Univ, Princeton Neurosci Inst, Princeton, NJ 08544 USA

来源：

NATURE COMMUNICATIONS | 2016年 / 7卷

关键词：

PARADOXICAL REM SLEEP; PONTOMESENCEPHALIC TEGMENTUM; PONTINE TEGMENTUM; WAKING CYCLE; BRAIN; RAT; WAKEFULNESS; INDUCTION; MICE; MICROINJECTION;

D O I：

10.1038/ncomms10763

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The dorsal pons has long been implicated in the generation of rapid eye movement (REM) sleep, but the underlying circuit mechanisms remain poorly understood. Using cell-type-specific microendoscopic Ca2+ imaging in and near the laterodorsal tegmental nucleus, we found that many glutamatergic neurons are maximally active during REM sleep (REM-max), while the majority of GABAergic neurons are maximally active during wakefulness (wake-max). Furthermore, the activity of glutamatergic neurons exhibits a medio-lateral spatial gradient, with medially located neurons more selectively active during REM sleep.

引用

页数：7

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