Molecular and Biological Aspects of the Bovine Immunodeficiency Virus

被引：10

作者：

Corredor, Andrea G. ^{[1
]}

St-Louis, Marie-Claude ^{[1
]}

Archambault, Denis ^{[1
]}

机构：

[1] Univ Quebec, Dept Biol Sci, Montreal, PQ H3C 3P8, Canada

来源：

CURRENT HIV RESEARCH | 2010年 / 8卷 / 01期

基金：

加拿大自然科学与工程研究理事会;

关键词：

Bovine immunodeficiency virus; structural proteins; Tat and Rev proteins; genetic diversity; JEMBRANA-DISEASE VIRUS; LONG TERMINAL REPEAT; INFECTIOUS-ANEMIA VIRUS; POLYMERASE-CHAIN-REACTION; SURFACE ENVELOPE GENE; LINKED-IMMUNOSORBENT-ASSAY; ELONGATION-FACTOR B; TYPE-1 TAT PROTEIN; RNA-BINDING DOMAIN; HIV-1; TAT;

D O I：

10.2174/157016210790416343

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The bovine immunodeficiency virus (BIV) was isolated in 1969 from a cow, R-29, with a wasting syndrome suggesting bovine leucosis. The virus, first designated bovine visna-like virus, remained unstudied until HIV was discovered in 1983. Then, it was demonstrated in 1987 that the bovine R-29 isolate was a lentivirus with striking similarity to the human immunodeficieny virus (HIV). Moreover, BIV has the most complex genomic structure among all identified lentiviruses shown by several regulatory/accessory genes encoding proteins, some of which are involved in the regulation of virus gene expression. This manuscript aims to review biological and molecular aspects of BIV, with emphasis on regulatory/accessory viral genes/proteins which are involved in virus expression.

引用

页码：2 / 13

页数：12

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