Cortical Enlightenment: Are Attentional Gamma Oscillations Driven by ING or PING?

被引:315
作者
Tiesinga, Paul [2 ,3 ]
Sejnowski, Terrence J. [1 ,4 ]
机构
[1] Salk Inst Biol Studies, Howard Hughes Med Inst, La Jolla, CA 92037 USA
[2] Radboud Univ Nijmegen, Donders Ctr Neurosci, NL-6525 ED Nijmegen, Netherlands
[3] Univ N Carolina, Dept Phys & Astron, Chapel Hill, NC 27599 USA
[4] Univ Calif San Diego, Div Biol Studies, La Jolla, CA 92093 USA
关键词
INTERNEURON NETWORKS; GAIN MODULATION; FIRE NEURONS; MODEL; CIRCUITS; MECHANISMS; SYNCHRONY; DYNAMICS; CORTEX; MICROSTIMULATION;
D O I
10.1016/j.neuron.2009.09.009
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The response of a neuron to sensory stimuli can only give correlational support for functional hypotheses. To experimentally test causal function, the neural activity needs to be manipulated in a cell-type-specific as well as spatially and temporally precise way. We review recent optogenetic experiments on parvalbumin-positive cortical interneurons that link modeling studies of synchronization to experimental studies on attentional modulation of gamma oscillations in primates.
引用
收藏
页码:727 / 732
页数:6
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