Discovery of a size-record breaking green-emissive fluorophore: small, smaller, HINA

被引：13
作者：
Kang, Rui [1 ]
Talamini, Laura [2 ]
D'Este, Elisa [3 ]
Estevao, Bianca Martins [2 ]
De Cola, Luisa [1 ,2 ]
Klopper, Wim [1 ,4 ]
Biedermann, Frank [1 ]
机构：
[1] Karlsruhe Inst Technol KIT, Inst Nanotechnol INT, Hermann Von Helmholtz Pl 1, D-76344 Eggenstein Leapaldshafen, Germany
[2] Univ Strasbourg, Inst Sci & Ingn Supramol ISIS, CNRS, 8Rue Gaspard Mange, F-67083 Strasbourg, France
[3] Max Plank Inst Med Res, Opt Microscopy Facil, Jahnstr 29, D-69120 Heidelberg, Germany
[4] Karlsruhe Inst Technol KIT, Inst Phys Chem IPC, Fritz Haber Weg 6, D-76131 Karlsruhe, Germany
来源：
CHEMICAL SCIENCE | 2021年 / 12卷 / 04期
基金：
巴西圣保罗研究基金会;
关键词：
53;
D O I：
10.1039/d0sc05557c
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Astonishingly, 3-hydroxyisonicotinealdehyde (HINA) is despite its small size a green-emitting push-pull fluorophore in water (QY of 15%) and shows ratiometric emission response to biological relevant pH differences (pK(a2) similar to 7.1). Moreover, HINA is the first small-molecule fluorophore reported that possesses three distinctly emissive protonation states. This fluorophore can be used in combination with metal complexes for fluorescent-based cysteine detection in aqueous media, and is readily taken up by cells. The theoretical description of HINA's photophysics remains challenging, even when computing Franck-Condon profiles via coupled-cluster calculations, making HINA an interesting model for future method development.
引用
收藏
页码：1392 / 1397
页数：6
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