Nonalcoholic Fatty Liver Disease and Obesity Treatment

被引：114

作者：

Brunner, Katherine T. ^{[1
]}

Henneberg, Cameron J. ^{[2
]}

Wilechansky, Robert M. ^{[3
]}

Long, Michelle T. ^{[1
]}

机构：

[1] Boston Univ, Sch Med, Boston Med Ctr, Gastroenterol Sect, 85 East Concord St 7th Floor, Boston, MA 02118 USA

[2] Boston Univ, Sch Med, Boston, MA 02118 USA

[3] Boston Univ, Sch Med, Evans Dept Med, Boston Med Ctr, Boston, MA 02118 USA

来源：

CURRENT OBESITY REPORTS | 2019年 / 8卷 / 03期

关键词：

Nonalcoholic fatty liver disease; Nonalcoholic steatohepatitis; Obesity; Diabetes; Body mass index; Magnetic resonance elastography; NAFLD activity score; Intrahepatic triglycerides; Bariatric surgery; Y GASTRIC BYPASS; LIFE-STYLE MODIFICATION; MEDITERRANEAN DIET; SLEEVE GASTRECTOMY; VITAMIN-E; CARDIOVASCULAR-DISEASE; HISTOLOGIC FEATURES; HEPATIC STEATOSIS; AEROBIC EXERCISE; GLYCEMIC INDEX;

D O I：

10.1007/s13679-019-00345-1

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose of ReviewNonalcoholic fatty liver disease (NAFLD), the most prevalent cause of chronic liver disease worldwide, is strongly associated with obesity and insulin resistance.Recent FindingsSignificant weight loss can improve NAFLD and nonalcoholic steatohepatitis (NASH). Diet and exercise that result in a sustained body weight reduction of 7-10% can improve liver fat content, NASH, and fibrosis. Vitamin E can be considered in patients with biopsy-proven NASH without diabetes, though caution must be used in those with prostate cancer. Pioglitazone improves liver histology, including fibrosis, and can be considered in patients with or without diabetes. Glucagon-like peptide-1 (GLP-1) antagonists may be beneficial in NASH, but more studies are needed before they can be recommended. Bariatric surgery, with resultant weight loss, can result in improvement in liver fat and inflammation.SummaryNAFLD treatment includes diet and exercise with a target 7-10% weight reduction. Treatment goals include improvements in liver fat content, liver inflammation, and fibrosis.

引用

页码：220 / 228

页数：9

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