Elevated serum YKL-40 levels in patients with Kawasaki disease

被引：4

作者：

Kim, K. Y. ^{[1
]}

Ahn, Y. ^{[2
,3
]}

Kim, D. Y. ^{[2
,3
]}

Kim, Ho-Seong ^{[1
]}

Kim, D. S. ^{[1
]}

机构：

[1] Yonsei Univ, Coll Med, Severance Childrens Hosp, Dept Pediat, 50 Yonsei Ro, Seoul 03722, South Korea

[2] Yonsei Univ, Coll Med, Dept Dermatol, Seoul, South Korea

[3] Yonsei Univ, Coll Med, Cutaneous Biol Res Inst, Seoul, South Korea

来源：

BIOMARKERS | 2017年 / 22卷 / 3-4期

关键词：

Kawasaki disease; acute phase reactant; YKL-40; CARDIOVASCULAR-DISEASE; RHEUMATOID-ARTHRITIS; HEPATIC-FIBROSIS; PLASMA YKL-40; BIOMARKER; CANCER; INFLAMMATION; PSORIASIS; SURVIVAL; INJURY;

D O I：

10.1080/1354750X.2016.1265000

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Context: YKL-40 is an inflammatory biomarker for endothelial dysfunction that may have a role in Kawasaki disease (KD).Objectives: We investigated the association of serum YKL-40 levels with KD and established laboratory parameters for YKL-40 levels and other inflammatory markers.Methods: YKL-40 levels and other inflammatory markers of 23 KD patients, 9 disease control patients and 11 age-matched healthy controls.Results: YKL-40 concentration in the serum of KD patients significantly increased during the acute disease phase compared with those of disease controls and healthy controls.Conclusions: Increased YKL-40 levels may provide a useful inflammatory marker for patients with KD.

引用

页码：326 / 330

页数：5

共 18 条

[1] Serum YKL-40 in psoriasis with and without arthritis; correlation with disease activity and high-resolution power Doppler ultrasonographic joint findings [J].