Elevated Circulating Stromal-Derived Factor-1 Levels in Sickle Cell Disease

被引：9

作者：

Landburg, P. P. ^{[1
,2
]}

Nur, E. ^{[3
,4
]}

Maria, N. ^{[1
,2
]}

Brandjes, D. P. M. ^{[3
]}

Biemond, B. J. ^{[4
]}

Schnog, J. B. ^{[1
,3
]}

Duits, A. J. ^{[1
]}

机构：

[1] Red Cross Blood Bank Fdn, Immunol Lab Dept, Curacao, Neth Antilles

[2] St Elizabeth Hosp, Dept Internal Med, Curacao, Neth Antilles

[3] Slotervaart Hosp, Dept Internal Med, Amsterdam, Netherlands

[4] Univ Amsterdam, Acad Med Ctr, Dept Haematol, NL-1105 AZ Amsterdam, Netherlands

来源：

ACTA HAEMATOLOGICA | 2009年 / 122卷 / 01期

关键词：

Sickle cell disease; Stromal derived factor-1; Pulmonary hypertension; ENDOTHELIAL GROWTH-FACTOR; PULMONARY-HYPERTENSION; ANGIOGENIC FACTORS; SERUM-LEVELS; PROGENITOR CELLS; FACTOR-1-ALPHA; RETINOPATHY; SDF-1; STATE; RECRUITMENT;

D O I：

10.1159/000243727

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Inflammation and angiogenesis are of importance in the pathophysiology of sickle cell disease (SCD). Recently, the chemokine stromal-derived factor-1 (SDF-1) has been shown to be a key mediator of angiogenesis and inflammation. In this study we determined serum SDF-1 levels in consecutive adult sickle cell patients during the clinically asymptomatic state as well as during painful crisis. Serum SDF-1 levels were significantly elevated in HbSS/HbS beta(0)-thalassaemia patients [n = 42; 5,177 pg/ml (2,438-7,246)] compared to HbSC/HbS beta(+)-thalassaemia patients [n = 16; 2,405 pg/ml (1,365-3,047)] and healthy HbAA controls [n = 45; 2,894 pg/ml (2,577-3,334)] (p = 0.001). No significant increments were observed during painful crisis (n = 40). SDF-1 levels were significantly higher in SCD patients with pulmonary hypertension (PHT) compared to patients without PHT. Elevated circulating SDF-1 levels occur in patients with SCD and may play a role in the pathophysiology of SCD-related PHT. Copyright (C) 2009 S. Karger AG, Basel

引用

页码：64 / 69

页数：6

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