New generation biologics for the treatment of psoriasis and psoriatic arthritis. State of the art and considerations about the risk of infection

被引：18
作者：
Ceccarelli, Manuela [1 ,2 ]
Rullo, Emmanuele Venanzi [3 ]
Berretta, Massimiliano [3 ]
Cacopardo, Bruno [1 ]
Pellicano, Giovanni Francesco [4 ]
Nunnari, Giuseppe [3 ]
Guarneri, Claudio [2 ]
机构：
[1] Univ Catania, Dept Clin & Expt Med, Unit Infect Dis, Catania, Italy
[2] Univ Messina, Dept Biomed & Dent Sci & Morpho Funct Imaging, Messina, Italy
[3] Univ Messina, Dept Clin & Expt Med, Unit Infect Dis, Messina, Italy
[4] Univ Messina, Dept Adult & Childhood Human Pathol Gaetano Barre, Messina, Italy
来源：
DERMATOLOGIC THERAPY | 2021年 / 34卷 / 01期
关键词：
infection; interleukin‐ 17; 23; psoriasis; psoriatic arthritis; SARS‐ CoV‐ 2; SERIOUS INFECTIONS; PLAQUE PSORIASIS; CLOSTRIDIUM-DIFFICILE; SAFETY; MULTICENTER; COVID-19; CHILDREN; RISANKIZUMAB; GUSELKUMAB; EFFICACY;
D O I：
10.1111/dth.14660
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Psoriasis is a chronic immune-mediated disease characterized by inflammation of skin (psoriasis) or joints (psoriatic arthritis) or both, resulting from a dysregulation in particular of the T helper (Th)17 functions. There is no available cure for psoriasis, and a life-long treatment is needed to control signs and symptoms. Research interest is high around the newest biological drugs approved for the treatment of moderate to severe psoriasis and psoriatic arthritis, and especially drugs blocking the IL-23/IL-17 axis. Our aim is to review the new biological drugs for the treatment of psoriasis and their adverse effects, focusing on the risk of infections.
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页数：7
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