Single-cell transcriptomics reveals specific RNA editing signatures in the human brain

被引：55
|
作者：
Picardi, Ernesto [1 ,2 ]
Horner, David S. [3 ]
Pesole, Graziano [1 ,2 ]
机构：
[1] Univ Bari, Dept Biosci Biotechnol & Biopharmaceut, I-70126 Bari, Italy
[2] CNR, Inst Biomembranes & Bioenerget, I-70126 Bad, Italy
[3] Univ Milan, Dept Biosci, I-20133 Milan, Italy
来源：
RNA | 2017年 / 23卷 / 06期
关键词：
RNA editing; single cell; RNA-seq; transcriptome; DNA; CONTRIBUTOR; DIVERSITY; TISSUES;
D O I：
10.1261/rna.058271.116
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
While RNA editing by A-to-I deamination is a requisite for neuronal function in humans, it is under-investigated in single cells. Here we fill this gap by analyzing RNA editing profiles of single cells from the brain cortex of living human subjects. We show that RNA editing levels per cell are bimodally distributed and distinguish between major brain cell types, thus providing new insights into neuronal dynamics.
引用
收藏
页码：860 / 865
页数：6
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