Single-cell transcriptomics reveals specific RNA editing signatures in the human brain

被引：55
|
作者：
Picardi, Ernesto [1 ,2 ]
Horner, David S. [3 ]
Pesole, Graziano [1 ,2 ]
机构：
[1] Univ Bari, Dept Biosci Biotechnol & Biopharmaceut, I-70126 Bari, Italy
[2] CNR, Inst Biomembranes & Bioenerget, I-70126 Bad, Italy
[3] Univ Milan, Dept Biosci, I-20133 Milan, Italy
来源：
RNA | 2017年 / 23卷 / 06期
关键词：
RNA editing; single cell; RNA-seq; transcriptome; DNA; CONTRIBUTOR; DIVERSITY; TISSUES;
D O I：
10.1261/rna.058271.116
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
While RNA editing by A-to-I deamination is a requisite for neuronal function in humans, it is under-investigated in single cells. Here we fill this gap by analyzing RNA editing profiles of single cells from the brain cortex of living human subjects. We show that RNA editing levels per cell are bimodally distributed and distinguish between major brain cell types, thus providing new insights into neuronal dynamics.
引用
收藏
页码：860 / 865
页数：6
相关论文
共 50 条
  • [21] Single-Cell Transcriptomics Analysis Reveals a Cell Atlas and Cell Communication in Yak Ovary
    Pei, Jie
    Xiong, Lin
    Guo, Shaoke
    Wang, Xingdong
    La, Yongfu
    Chu, Min
    Liang, Chunnian
    Yan, Ping
    Guo, Xian
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (03)
  • [22] Single-nucleus transcriptome analysis reveals cell-type-specific molecular signatures across reward circuitry in the human brain
    Tran, Matthew N.
    Maynard, Kristen R.
    Spangler, Abby
    Huuki, Louise A.
    Montgomery, Kelsey D.
    Sadashivaiah, Vijay
    Tippani, Madhavi
    Barry, Brianna K.
    Hancock, Dana B.
    Hicks, Stephanie C.
    Kleinman, Joel E.
    Hyde, Thomas M.
    Collado-Torres, Leonardo
    Jaffe, Andrew E.
    Martinowich, Keri
    NEURON, 2021, 109 (19) : 3088 - +
  • [23] Single-Cell RNA Sequencing: Unraveling the Brain One Cell at a Time
    Ofengeim, Dimitry
    Giagtzoglou, Nikolaos
    Huh, Dann
    Zou, Chengyu
    Yuan, Junying
    TRENDS IN MOLECULAR MEDICINE, 2017, 23 (06) : 563 - 576
  • [24] Sequencing the Human Brain at Single-Cell Resolution
    Maitra, Malosree
    Nagy, Corina
    Turecki, Gustavo
    CURRENT BEHAVIORAL NEUROSCIENCE REPORTS, 2019, 6 (04) : 197 - 208
  • [25] Plant Cell Identity in the Era of Single-Cell Transcriptomics
    Ryu, Kook Hui
    Zhu, Yan
    Schiefelbein, John
    ANNUAL REVIEW OF GENETICS, VOL 55, 2021, 55 : 479 - 496
  • [26] Single-Cell RNA Sequencing Reveals Atlas of Yak Testis Cells
    Wang, Xingdong
    Pei, Jie
    Xiong, Lin
    Guo, Shaoke
    Cao, Mengli
    Kang, Yandong
    Ding, Ziqiang
    La, Yongfu
    Liang, Chunnian
    Yan, Ping
    Guo, Xian
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (09)
  • [27] Single-Cell RNA Sequencing for Studying Human Cancers
    Aran, Dvir
    ANNUAL REVIEW OF BIOMEDICAL DATA SCIENCE, 2023, 6 : 1 - 22
  • [28] Bioinformatics perspectives on transcriptomics: A comprehensive review of bulk and single-cell RNA sequencing analyses
    Tzec-Interian, Jorge A.
    Gonzalez-Padilla, Daianna
    Gongora-Castillo, Elsa B.
    QUANTITATIVE BIOLOGY, 2025, 13 (02)
  • [29] Single-cell RNA sequencing reveals dynamic changes in A-to-I RNA editome during early human embryogenesis
    Qiu, Si
    Li, Wenhui
    Xiong, Heng
    Liu, Dongbing
    Bai, Yali
    Wu, Kui
    Zhang, Xiuqing
    Yang, Huanming
    Ma, Kun
    Hou, Yong
    Li, Bo
    BMC GENOMICS, 2016, 17
  • [30] Single-cell transcriptomics in thyroid eye disease
    Ahsanuddin, Sofia
    Wu, Albert Y.
    TAIWAN JOURNAL OF OPHTHALMOLOGY, 2024, 14 (04) : 554 - 564
12345