Treatment Outcomes With Pegylated Interferon and Ribavirin for Male Prisoners With Chronic Hepatitis C

lGoals: To report our experience with pegylated interferon and ribavirin treatment of hepatitis C virus (HCV) RNA-positive inmates at the Rhode Island Department of Corrections. Background: An estimated I out of 3 HCV-infected individuals will spend time in it jail or prison within a I-year period, making prisons a unique setting for management of chronic HCV. Study: Chart review of all inmates identified as having initiated HCV treatment between October 2000 and April 2004, HCV-infected individuals were identified by HCV antibody screening at intake for known risk factors, elevated aminotransferase levels. or per individual request. Treatment followed standard guidelines with weight-based dosing of pegylated interferon-alpha 2b and ribavirin. End points were completion of therapy plus 6 months for sustained virologic response (SVR), therapy discontinuation. and loss to follow-up. Results: The cohort included 71 male patients, was mostly white (80%). and genotype 1 (65%). All 9 African Americans (AA) had genotype 1. Of 59 patient,, having liver biopsy, 41 had early stage disease. Overall SVR was 28%. Response rate was lower for genotype I compared with genotypes 2 and 3 (SVR 18% vs. 60% and 50%). Of inmates with genotype 1, no difference existed in treatment response by race (SVR 22% AA vs. 18% white). Thirty-three patients completed treatment, 26 stopped for side effects. and 5 for initial nonresponse. Eleven were lost to follow-tip. Conclusions: Acceptable HCV treatment outcomes can be achieved in prisons. Our small study indicates no difference in treatment response by AA versus white race for genotype 1.