A comparison of imaging methods for use in an array biosensor

被引：44

作者：

Golden, JP ^{[1
]}

Ligler, FS ^{[1
]}

机构：

[1] USN, Res Lab, Ctr Biomol Sci & Engn, Washington, DC 20375 USA

来源：

BIOSENSORS & BIOELECTRONICS | 2002年 / 17卷 / 09期

关键词：

CMOS; CCD; florescence; biosensor; array sensor;

D O I：

10.1016/S0956-5663(02)00060-X

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

An array biosensor has been developed which uses an actively-cooled, charge-coupled device (CCD) imager. In an effort to save money and space, a complementary metal-oxide semiconductor (CMOS) camera and photodiode were tested as replacements for the cooled CCD imager. Different concentrations of CY5 fluorescent dye in glycerol were imaged using the three different detection systems with the same imaging optics. Signal discrimination above noise was compared for each of the three systems. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：719 / 725

页数：7

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