Typhlitis during second-line chemotherapy with pemetrexed in non-small cell lung cancer (NSCLC): A case report

被引：8

作者：

Tiseo, Marcello ^{[1
]}

Gelsomino, Francesco ^{[1
]}

Bartolotti, Marco ^{[1
]}

Barili, Matteo Pesenti ^{[2
]}

Ardizzoni, Andrea ^{[1
]}

机构：

[1] Univ Hosp Parma, Med Oncol Unit, I-43100 Parma, Italy

[2] Univ Hosp Parma, Radiol Unit, I-43100 Parma, Italy

来源：

LUNG CANCER | 2009年 / 65卷 / 02期

关键词：

Typhlitis; Pemetrexed; Non-small cell lung cancer; Second line; Chemotherapy; Neutropenia; NEUTROPENIC ENTEROCOLITIS; PHASE-III; ADULTS; CISPLATIN; DOCETAXEL; THERAPY;

D O I：

10.1016/j.lungcan.2009.02.021

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Neutropenic enterocolitis, or typhlitis, is an unusual acute complication of chemotherapy-induced neutropenia, characterized by inflammatory process involving colon and/or small bowel that may progress to necrosis, haemorrhage, perforation and septicaemia. Typhlitis is usually seen in the setting of severe chemotherapy-induced neutropenia for acute leukaemia. Nevertheless, it is increasingly recognized as a complication of therapy in solid tumors. We present a case of typhlitis in a patient with advanced non-small cell lung cancer (NSCLC) who received pemetrexed, as second-line chemotherapy treatment. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

引用

页码：251 / 253

页数：3

共 18 条

[1]

Bagnoli P, 2007, TUMORI, V93, P608

[2] Neutropenic enterocolitis in adults: Case series and review of the literature [J].

Cunningham, SC ;

Fakhry, K ;

Bass, BL ;

Napolitano, LM .

DIGESTIVE DISEASES AND SCIENCES, 2005, 50 (02) :215-220

[3] Neutropenic enterocolitis (typhi litis) associated with docetaxel therapy in a patient with non-small-cell lung cancer: case report and review of literature [J].

D'Amato, G ;

Lima, CR ;

Mahany, JJ ;

Muro-Cacho, C ;

Haura, EB .

LUNG CANCER, 2004, 44 (03) :381-390

[4] Neutropenic enterocolitis [J].

Davila M.L. .

Current Treatment Options in Gastroenterology, 2006, 9 (3) :249-255

[5] Neutropenic enterocolitis: Current issues in diagnosis and management [J].

Davila M.L. .

Current Infectious Disease Reports, 2007, 9 (2) :116-120

[6]

ETTINGHAUSEN SE, 1993, SURG CLIN N AM, V73, P993

[7] Neutropenic enterocolitis in adults:: systematic analysis of evidence quality [J].

Gorschlüter, M ;

Mey, U ;

Strehl, J ;

Ziske, C ;

Schepke, M ;

Schmidt-Wolf, IGH ;

Sauerbruch, T ;

Glasmacher, A .

EUROPEAN JOURNAL OF HAEMATOLOGY, 2005, 75 (01) :1-13

[8] Second-line treatment of advanced non-small cell lung cancer [J].

Gridelli, Cesare ;

Ardizzoni, Andrea ;

Ciardiello, Fortunato ;

Hanna, Nasser ;

Heymach, John V. ;

Perrone, Francesco ;

Rosell, Rafael ;

Shepherd, Frances A. ;

Thatcher, Nick ;

Vansteenkiste, Johan ;

De Petris, Luigi ;

Di Maio, Massimo ;

De Marinis, Filippo .

JOURNAL OF THORACIC ONCOLOGY, 2008, 3 (04) :430-440

[9] Pemetrexed disodium: A novel Antifolate clinically active against multiple solid tumors [J].

Hanauske, AR ;

Chen, V ;

Paoletti, P ;

Niyikiza, C .

ONCOLOGIST, 2001, 6 (04) :363-373

[10] Randomized phase III trial of pemetrexed versus docetaxel in patients with non-small-cell lung cancer previously treated with chemotherapy [J].

Hanna, N ;

Shepherd, FA ;

Fossella, FV ;

Pereira, JR ;

De Marinis, F ;

von Pawel, J ;

Gatzemeier, U ;

Tsao, TCY ;

Pless, M ;

Muller, T ;

Lim, HL ;

Desch, C ;

Szondy, K ;

Gervais, R ;

Shaharyar ;

Manegold, C ;

Paul, S ;

Paoletti, P ;

Einhorn, L ;

Bunn, PA .

JOURNAL OF CLINICAL ONCOLOGY, 2004, 22 (09) :1589-1597

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