Therapeutic effect of anti-feline TNF-alpha monoclonal antibody for feline infectious peritonitis

被引：14
作者：
Doki, Tomoyoshi [1 ]
Takano, Tomomi [1 ]
Kawagoe, Kohei [1 ]
Kito, Akihiko [1 ]
Hohdatsu, Tsutomu [1 ]
机构：
[1] Kitasato Univ, Sch Vet Med, Lab Vet Infect Dis, Towada, Aomori 0348628, Japan
来源：
RESEARCH IN VETERINARY SCIENCE | 2016年 / 104卷
关键词：
Feline coronavirus; Feline infectious peritonitis; Tumor necrosis factor-alpha; NECROSIS-FACTOR-ALPHA; SPIKE PROTEIN; ALPHA-1-ACID GLYCOPROTEIN; CORONAVIRUS INFECTION; VIRUS; CATS; MACROPHAGES; EXPRESSION; INDUCTION; CORRELATE;
D O I：
10.1016/j.rvsc.2015.11.005
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
Feline infectious peritonitis virus (FIPV) replication in macrophages/monocytes induced tumor necrosis factor (TNF)-alpha production, and that the TNF-alpha produced was involved in aggravating the pathology of HP. We previously reported the preparation of a feline TNF-alpha (fTNF-alpha)-neutralizing mouse monoclonal antibody (anti-frNF-alpha mAb). This anti-fINF-alpha mAb 2-4 was confirmed to inhibit the following fTNF-alpha-induced conditions in vitro. In the present study, we investigated whether mAb 2-4 improved the HP symptoms and survival rate of experimentally FIPV-inoculated SPF cats. Progression to FIP was prevented in 2 out of 3 cats treated with mAb 2-4, whereas all 3 cats developed FIP in the placebo control group. Plasma alphal-glycoprotein and vascular endothelial growth factor levels were improved by the administration of mAb 2-4, and the peripheral lymphocyte count also recovered. These results strongly suggested that the anti-fTNF-alpha antibody is effective for the treatment of HP. (C) 2015 Elsevier Ltd. All rights reserved.
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收藏
页码：17 / 23
页数：7
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