Bioactive milk peptides and blood pressure

被引：0

作者：

Jauhiainen, Tiina ^{[1
,2
]}

Korpela, Riitta ^{[1
,2
]}

Vapaatalo, Heikki ^{[1
]}

Turpeinen, Anu M. ^{[2
]}

Kautiainen, Hannu ^{[3
]}

机构：

[1] Univ Helsinki, Inst Biomed, FIN-00014 Helsinki, Finland

[2] Valio Ltd, Res & Dev, Helsinki 00039, Finland

[3] Medcare Ltd, Aanekoski 44100, Finland

来源：

AGRO FOOD INDUSTRY HI-TECH | 2009年 / 20卷 / 02期

关键词：

meta-analysis; blood pressure; clinical trial; milk derived peptides; FERMENTED MILK; SOUR MILK; METAANALYSIS; HYPERTENSION; TRIPEPTIDES; POTASSIUM;

D O I：

暂无

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We have shown in several clinical trials that the milk protein-derived bioactive peptides isoleucine-proline-proline (IPP) and valine-proline-proline (VPP) lower blood pressure, but a critical meta-analysis had yet to be conducted based on these studies. A total of five randomized controlled clinical trials with 295 voluntary subjects were included in the meta-analysis. The overall effect in the meta-analysis was a -4.0 mmHg (95 percent Cl:-5.9 to -2.1, p<0.001) reduction in systolic blood pressure and -2.1 mmHg (95 percent Cl:-3.4 to -0.8, p=0.002) reduction in diastolic blood pressure. The meta-analysis confirms that Lactobacillus helveticus fermented milk containing IPP and VPP tripeptides reduces blood pressure in hypertensive subjects. Functional foods containing bioactive milk peptides can be useful as part of dietary treatment and prevention of hypertension.

引用

页码：26 / 28

页数：3

共 19 条

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