Identification of Viable Embryos Using Deep Learning for Medical Image

被引:9
作者
Cao, Qiang [1 ]
Liao, Stephen Shaoyi [1 ]
Meng, Xiangqian [2 ]
Ye, Han [1 ]
Yan, Zhenbin [1 ,3 ]
Wang, Puxi [1 ]
机构
[1] City Univ Hong Kong, Dept Informat Syst, Hong Kong, Peoples R China
[2] Sincere Care IVF, Chengdu, Sichuan, Peoples R China
[3] Univ Sci & Technol China, Sch Management, Hefei, Peoples R China
来源
ICBRA 2018: PROCEEDINGS OF 2018 5TH INTERNATIONAL CONFERENCE ON BIOINFORMATICS RESEARCH AND APPLICATIONS | 2018年
关键词
Deep learning; Medical image classification; Assisted reproduction technology; CLASSIFICATION; SELECTION;
D O I
10.1145/3309129.3309143
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Identifying viable embryos for implantation is one of the most relevant aspects in assisted reproductive technology. However, embryo selection highly depends on visual examination by embryologists via microscopy, and their evaluations are often subjective. The rapid growth of image processing technology has resulted in increased interest in the use of machine learning methods for embryo selection in in vitro fertilization (IVF) programs. The present study uses deep learning method for the morphological classification of embryos based on medical images. The proposed system is trained and tested on a real data set of 1,310 images from 344 embryos and evaluated by comparison with other traditional machine learning methods to solve similar classification problems. The results indicate that our new deep learning model significantly outperforms other methods. Our work contributes immensely to the fields of assisted reproductive technology, medical image processing, and decision support system design.
引用
收藏
页码:69 / 72
页数:4
相关论文
共 21 条
[1]  
[Anonymous], 2018, SART NATL SUMMARY RE
[2]   Using machine learning to speed up manual image annotation: application to a 3D imaging protocol for measuring single cell gene expression in the developing C. elegans embryo [J].
Aydin, Zafer ;
Murray, John I. ;
Waterston, Robert H. ;
Noble, William S. .
BMC BIOINFORMATICS, 2010, 11
[3]   Computer-aided diagnosis in medical imaging: Historical review, current status and future potential [J].
Doi, Kunio .
COMPUTERIZED MEDICAL IMAGING AND GRAPHICS, 2007, 31 (4-5) :198-211
[4]   Single blastocyst transfer: a prospective randomized trial [J].
Gardner, DK ;
Surrey, E ;
Minjarez, D ;
Leitz, A ;
Stevens, J ;
Schoolcraft, WB .
FERTILITY AND STERILITY, 2004, 81 (03) :551-555
[5]   Identifying Medical Diagnoses and Treatable Diseases by Image-Based Deep Learning [J].
Kermany, Daniel S. ;
Goldbaum, Michael ;
Cai, Wenjia ;
Valentim, Carolina C. S. ;
Liang, Huiying ;
Baxter, Sally L. ;
McKeown, Alex ;
Yang, Ge ;
Wu, Xiaokang ;
Yan, Fangbing ;
Dong, Justin ;
Prasadha, Made K. ;
Pei, Jacqueline ;
Ting, Magdalena ;
Zhu, Jie ;
Li, Christina ;
Hewett, Sierra ;
Dong, Jason ;
Ziyar, Ian ;
Shi, Alexander ;
Zhang, Runze ;
Zheng, Lianghong ;
Hou, Rui ;
Shi, William ;
Fu, Xin ;
Duan, Yaou ;
Huu, Viet A. N. ;
Wen, Cindy ;
Zhang, Edward D. ;
Zhang, Charlotte L. ;
Li, Oulan ;
Wang, Xiaobo ;
Singer, Michael A. ;
Sun, Xiaodong ;
Xu, Jie ;
Tafreshi, Ali ;
Lewis, M. Anthony ;
Xia, Huimin ;
Zhang, Kang .
CELL, 2018, 172 (05) :1122-+
[6]  
LeCun Y., 1998, P IEEE, P2
[7]   Autonomous detection of pulmonary nodules on CT images with a neural network-based fuzzy system [J].
Lin, DT ;
Yan, CR ;
Chen, WT .
COMPUTERIZED MEDICAL IMAGING AND GRAPHICS, 2005, 29 (06) :447-458
[8]   Experimental results on the recognition of embryos in human assisted reproduction [J].
Manna, C ;
Patrizi, G ;
Rahman, A ;
Sallam, H .
REPRODUCTIVE BIOMEDICINE ONLINE, 2004, 8 (04) :460-469
[9]   Artificial intelligence techniques for embryo and oocyte classification [J].
Manna, Claudio ;
Nanni, Loris ;
Lumini, Alessandra ;
Pappalardo, Sebastiana .
REPRODUCTIVE BIOMEDICINE ONLINE, 2013, 26 (01) :42-49
[10]   Selection of human embryos for transfer by Bayesian classifiers [J].
Morales, Dinora A. ;
Bengoetxea, Endika ;
Larranaga, Pedro .
COMPUTERS IN BIOLOGY AND MEDICINE, 2008, 38 (11-12) :1177-1186