Highly diastereo- and enantioselective Mukaiyama aldol reactions catalyzed by hydrogen bonding

被引：80

作者：

McGilvra, Jeff D. ^{[1
]}

Unni, Aditya K. ^{[1
]}

Modi, Kriti ^{[1
]}

Rawal, Viresh H. ^{[1
]}

机构：

[1] Univ Chicago, Dept Chem, Chicago, IL 60637 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 37期

关键词：

asymmetric catalysis; enantioselectivity; hydrogen bonds; Mukaiyama aldol; organocatalysis;

D O I：

10.1002/anie.200601638

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Enzyme lite: Like a minimalist enzyme, a simple chiral alcohol of the taddol family, 1, catalyzes Mukaiyama aldol reactions between silyl enolates of amides and aldehydes to afford products with high diastereo- and enantioselectivities (see scheme; TBS = tert-butyldimethylsilyl). © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：6130 / 6133

页数：4

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