Validation of an echocardiographic assessment of cardiac function following moderate size myocardial infarction in the rat

被引:33
作者
Burrell, LM
Chan, R
Phillips, PA
Calafiore, P
Tonkin, AM
Johnston, CI
机构
关键词
echocardiography; hypertrophy; left ventricle; myocardial infarction;
D O I
10.1111/j.1440-1681.1996.tb02782.x
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
1. The present study determined whether two dimensional guided hi-mode echocardiography could assess left ventricular (LV) geometry and function following a moderate size myocardial infarction in the rat. 2. Myocardial infarction (MI) was induced by left coronary artery ligation and rats were studied 4 weeks later, Infarct rats showed increased LV internal diastolic diameter (7.33 +/- 0.8 vs 5.91 +/- 0.6 mm; P<0.001), LV systolic diameter (3.73 +/- 1.2 vs 1.87 +/- 0.6 mm; P<0.001) and thickening of the noninfarcted posterior wall compared with sham operated rats (1.81 +/- 0.2 vs 1.47 +/- 0.3; P<0.001; n = 10/group; mean +/- s.d.). Systolic function was impaired in infarct rats who showed reduced fractional shortening (50 +/- 12 vs 68 +/- 9%; P<0.001) and fractional area change (41 +/- 14 vs 78 +/- 5%; P<0.001). Infarct size measured echocardiographically was comparable to that measured by quantitative histological examination (29 +/- 10 vs 28 +/- 5%; NS). 3. The present study indicates that postinfarction remodelling leading to LV cavity dilation, hypertrophy of surviving myocardium and impaired systolic function is apparent 4 weeks following moderate size MI in the rat. 4. Transthoracic echocardiography is a noninvasive technique that may be used to assess serially the efficacy of therapeutic interventions designed to prevent remodelling in moderate size MI in the rat.
引用
收藏
页码:570 / 572
页数:3
相关论文
共 8 条
[1]  
BURRELL LM, 1996, IN PRESS J HYPERTENS
[2]  
FARINA NK, 1996, IN PRESS J HYPERTENS
[3]   NEUROHUMORAL RESPONSES TO CHRONIC MYOCARDIAL-INFARCTION IN RATS [J].
HODSMAN, GP ;
KOHZUKI, M ;
HOWES, LG ;
SUMITHRAN, E ;
TSUNODA, K ;
JOHNSTON, CI .
CIRCULATION, 1988, 78 (02) :376-381
[4]   DEVELOPMENT AND VALIDATION OF ECHOCARDIOGRAPHIC METHODS FOR ESTIMATING LEFT-VENTRICULAR MASS IN RATS [J].
JONES, EF ;
HARRAP, SB ;
CALAFIORE, P ;
TONKIN, AM .
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 1992, 19 (05) :361-364
[5]   SERIAL ECHOCARDIOGRAPHIC ASSESSMENT OF LEFT-VENTRICULAR GEOMETRY AND FUNCTION AFTER LARGE MYOCARDIAL-INFARCTION IN THE RAT [J].
LITWIN, SE ;
KATZ, SE ;
MORGAN, JP ;
DOUGLAS, PS .
CIRCULATION, 1994, 89 (01) :345-354
[6]   VENTRICULAR REMODELING AFTER MYOCARDIAL-INFARCTION - EXPERIMENTAL-OBSERVATIONS AND CLINICAL IMPLICATIONS [J].
PFEFFER, MA ;
BRAUNWALD, E .
CIRCULATION, 1990, 81 (04) :1161-1172
[7]   SURVIVAL AFTER AN EXPERIMENTAL MYOCARDIAL-INFARCTION - BENEFICIAL-EFFECTS OF LONG-TERM THERAPY WITH CAPTOPRIL [J].
PFEFFER, MA ;
PFEFFER, JM ;
STEINBERG, C ;
FINN, P .
CIRCULATION, 1985, 72 (02) :406-412
[8]   RECOMMENDATIONS REGARDING QUANTITATION IN M-MODE ECHOCARDIOGRAPHY - RESULTS OF A SURVEY OF ECHOCARDIOGRAPHIC MEASUREMENTS [J].
SAHN, DJ ;
DEMARIA, A ;
KISSLO, J ;
WEYMAN, A .
CIRCULATION, 1978, 58 (06) :1072-1083