The Role of WNT in Rheumatoid Arthritis and its Therapeutic Implication

被引：7
|
作者：
Imai, Kazushi [1 ]
Chiba, Tadashige [1 ]
Maeda, Genta [1 ]
Morikawa, Masako [1 ]
机构：
[1] Nippon Dent Univ Tokyo, Sch Life Dent Tokyo, Dept Biochem, Chiyoda Ku, Tokyo 1028159, Japan
来源：
MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2009年 / 9卷 / 03期
关键词：
WNT; rheumatoid arthritis; FRP; beta-catenin; synovium; matrix metalloproteinase; BETA-CATENIN; TRANSCRIPTIONAL ACTIVITY; GENE-EXPRESSION; BONE-FORMATION; ESTROGEN; FIBROBLAST; FAMILY; CANCER; DIFFERENTIATION; ANTAGONIST;
D O I：
10.2174/1389557510909030318
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Rheumatoid arthritis (RA) is a systematic inflammatory and intractable disease, which progressively affects multiple joints. Recent findings strongly suggest a key role of WNT signaling in the disease initiation and progression. In this review, we discuss the role and possibility of treatment by targeting WNT signaling.
引用
收藏
页码：318 / 323
页数：6
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