The Role of WNT in Rheumatoid Arthritis and its Therapeutic Implication

被引：7

作者：

Imai, Kazushi ^{[1
]}

Chiba, Tadashige ^{[1
]}

Maeda, Genta ^{[1
]}

Morikawa, Masako ^{[1
]}

机构：

[1] Nippon Dent Univ Tokyo, Sch Life Dent Tokyo, Dept Biochem, Chiyoda Ku, Tokyo 1028159, Japan

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2009年 / 9卷 / 03期

关键词：

WNT; rheumatoid arthritis; FRP; beta-catenin; synovium; matrix metalloproteinase; BETA-CATENIN; TRANSCRIPTIONAL ACTIVITY; GENE-EXPRESSION; BONE-FORMATION; ESTROGEN; FIBROBLAST; FAMILY; CANCER; DIFFERENTIATION; ANTAGONIST;

D O I：

10.2174/1389557510909030318

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Rheumatoid arthritis (RA) is a systematic inflammatory and intractable disease, which progressively affects multiple joints. Recent findings strongly suggest a key role of WNT signaling in the disease initiation and progression. In this review, we discuss the role and possibility of treatment by targeting WNT signaling.

引用

页码：318 / 323

页数：6

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