25 Years of Neuroendocrine Neoplasms of the Gastrointestinal Tract

被引：12

作者：

Rindi, G. ^{[1
]}

Petrone, G. ^{[1
]}

Inzani, F. ^{[1
]}

机构：

[1] Univ Cattolica Sacro Cuore, Policlin A Gemelli, Inst Pathol, I-00168 Rome, Italy

来源：

ENDOCRINE PATHOLOGY | 2014年 / 25卷 / 01期

关键词：

Tumor; Carcinoma; Endocrine; Neuroendocrine; Immunohistochemistry; Chormogranin A; Synaptophysin; Ki67; HORMONE-PRODUCING CELLS; ENDOCRINE TUMORS; HELICOBACTER-PYLORI; TRANSGENIC MICE; NEURAL CREST; PROGNOSTIC-FACTORS; GRADING SYSTEM; CHROMOGRANIN; CARCINOIDS; SURVIVAL;

D O I：

10.1007/s12022-013-9292-5

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This paper provides a personal pathologist's view of how neuroendocrine tumors (NET) were perceived and defined in the last quarter of a century. In years when the Helicobacter pylori, omeprazole and the adenoma-carcinoma sequence in colon carcinogenesis significantly impacted on gastrointestinal (GI) pathology daily practice, neuroendocrine neoplasms of the GI tract passed from the original carcinoid definition to the current NET and neuroendocrine carcinoma (NEC) definitions. The development of different concepts, basic tumor biology knowledge, tools for pathology diagnosis and the various World Health Organization (WHO) classifications from 1980 through 2010 are briefly reviewed and discussed.

引用

页码：59 / 64

页数：6

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