Emergence of the Primary Pediatric Stroke Center Impact of the Thrombolysis in Pediatric Stroke Trial

被引：96

作者：

Bernard, Timothy J. ^{[1
]}

Rivkin, Michael J. ^{[2
,3
,4
]}

Scholz, Kelley ^{[26
]}

deVeber, Gabrielle ^{[5
]}

Kirton, Adam ^{[6
]}

Gill, Joan Cox ^{[7
,8
,12
]}

Chan, Anthony K. ^{[9
]}

Hovinga, Collin A. ^{[10
]}

Ichord, Rebecca N. ^{[11
]}

Grotta, James C.

Jordan, Lori C. ^{[13
]}

Benedict, Susan ^{[14
]}

Friedman, Neil R. ^{[15
]}

Dowling, Michael M. ^{[16
]}

Elbers, Jorina ^{[17
]}

Torres, Marcela ^{[18
]}

Sultan, Sally ^{[19
]}

Cummings, Dana D. ^{[20
]}

Grabowski, Eric F. ^{[21
,22
]}

McMillan, Hugh J. ^{[23
]}

Beslow, Lauren A. ^{[24
,25
]}

Amlie-Lefond, Catherine ^{[26
,27
]}

机构：

[1] Childrens Hosp Colorado, Dept Neurol, Aurora, CO USA

[2] Boston Childrens Hosp, Dept Neurol, Boston, MA USA

[3] Boston Childrens Hosp, Dept Psychiat, Boston, MA USA

[4] Boston Childrens Hosp, Dept Radiol, Boston, MA USA

[5] Hosp Sick Children, Dept Neurol, Toronto, ON M5G 1X8, Canada

[6] Univ Calgary, Alberta Childrens Hosp Res Inst, Dept Neurol, Calgary, AB, Canada

[7] Med Coll Wisconsin, Dept Pediat, Milwaukee, WI 53226 USA

[8] BloodCtr Wisconsin, Milwaukee, WI USA

[9] McMaster Univ, Dept Pediat, Hamilton, ON, Canada

[10] Dell Childrens Med Ctr, Dept Pediat, Austin, TX USA

[11] Univ Penn, Sch Med, Dept Neurol, Philadelphia, PA 19104 USA

[12] Mem Hermann Hosp, Dept Neurol, Houston, TX USA

[13] Vanderbilt Univ, Div Pediat Neurol, Nashville, TN 37235 USA

[14] Primary Childrens Med Ctr, Dept Neurol, Salt Lake City, UT 84103 USA

[15] Cleveland Clin, Dept Neurol, Cleveland, OH USA

[16] UT Southwestern Med Ctr, Dept Pediat & Neurol, Dallas, TX USA

[17] Stanford Univ, Dept Neurol, Stanford, CA 94305 USA

[18] Cook Childrens Med Ctr, Dept Hematol & Oncol, Ft Worth, TX USA

[19] Columbia Univ, Dept Neurol, Med Ctr, New York, NY USA

[20] Univ Pittsburgh, Childrens Hosp Pittsburgh, Div Child Neurol, Med Ctr, Pittsburgh, PA 15260 USA

[21] Mass Gen Hosp Children, Dept Pediat, Div Pediat Hematol Oncol, Boston, MA USA

[22] Massachusetts Gen Hosp, Boston, MA 02114 USA

[23] Childrens Hosp Eastern Ontario, Dept Neurol, Ottawa, ON K1H 8L1, Canada

[24] Yale New Haven Childrens Hosp, Dept Pediat, New Haven, CT USA

[25] Yale New Haven Childrens Hosp, Dept Neurol, New Haven, CT USA

[26] Seattle Childrens Hosp, Dept Neurol, Seattle, WA USA

[27] Univ Washington, Dept Neurol, Seattle, WA 98105 USA

来源：

STROKE | 2014年 / 45卷 / 07期

基金：

美国国家卫生研究院;

关键词：

child; stroke; thrombolytic therapy; ARTERIAL ISCHEMIC-STROKE; EARLY MANAGEMENT; CHILDREN; ASSOCIATION; GUIDELINES; COUNCIL; DISEASE;

D O I：

10.1161/STROKEAHA.114.004919

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background and Purpose-In adult stroke, the advent of thrombolytic therapy led to the development of primary stroke centers capable to diagnose and treat patients with acute stroke rapidly. We describe the development of primary pediatric stroke centers through preparation of participating centers in the Thrombolysis in Pediatric Stroke (TIPS) trial. Methods-We collected data from the 17 enrolling TIPS centers regarding the process of becoming an acute pediatric stroke center with capability to diagnose, evaluate, and treat pediatric stroke rapidly, including use of thrombolytic therapy. Results-Before 2004, <25% of TIPS sites had continuous 24-hour availability of acute stroke teams, MRI capability, or stroke order sets, despite significant pediatric stroke expertise. After TIPS preparation, >80% of sites now have these systems in place, and all sites reported increased readiness to treat a child with acute stroke. Use of a 1- to 10-Likert scale on which 10 represented complete readiness, median center readiness increased from 6.2 before site preparation to 8.7 at the time of site activation (P <= 0.001). Conclusions-Before preparing for TIPS, centers interested in pediatric stroke had not developed systematic strategies to diagnose and treat acute pediatric stroke. TIPS trial preparation has resulted in establishment of pediatric acute stroke centers with clinical and system preparedness for evaluation and care of children with acute stroke, including use of a standardized protocol for evaluation and treatment of acute arterial stroke in children that includes use of intravenous tissue-type plasminogen activator.

引用

页码：2018 / 2023

页数：6

共 17 条

[1] Guidelines for the early management of adults with ischemic stroke - A guideline from the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the atherosclerotic peripheral vascular disease and quality of care outcomes in research interdisciplinary working groups [J].

Adams, Harold P., Jr. ;

del Zoppo, Gregory ;

Alberts, Mark J. ;

Bhatt, Deepak L. ;

Brass, Lawrence ;

Furlan, Anthony ;

Grubb, Robert L. ;

Higashida, Randall T. ;

Jauch, Edward C. ;

Kidwell, Chelsea ;

Lyden, Patrick D. ;

Morgenstern, Lewis B. ;

Qureshi, Adnan I. ;

Rosenwasser, Robert H. ;

Scott, Phillip A. ;

Wijdicks, Eelco F. M. .

STROKE, 2007, 38 (05) :1655-1711

[2]

Adams R, 2002, STROKE, V33, P326

[3] Recommendations for the establishment of primary stroke centers [J].

Alberts, MJ ;

Hademenos, G ;

Latchaw, RE ;

Jagoda, A ;

Marler, JR ;

Mayberg, MR ;

Starke, RD ;

Todd, HW ;

Viste, KM ;

Girgus, M ;

Shephard, T ;

Emr, M ;

Shwayder, P ;

Walker, MD .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2000, 283 (23) :3102-3109

[4] Use of alteplase in childhood arterial ischaemic stroke: a multicentre, observational, cohort study [J].

Amlie-Lefond, Catherine ;

deVeber, Gabrielle ;

Chan, Anthony K. ;

Benedict, Susan ;

Bernard, Timothy ;

Carpenter, Jessica ;

Dowling, Michael M. ;

Fullerton, Heather ;

Hovinga, Collin ;

Kirton, Adam ;

Lo, Warren ;

Zamel, Khaled ;

Ichord, Rebecca .

LANCET NEUROLOGY, 2009, 8 (06) :530-536

[5] Concurrent Validity and Reliability of Retrospective Scoring of the Pediatric National Institutes of Health Stroke Scale [J].

Beslow, Lauren A. ;

Kasner, Scott E. ;

Smith, Sabrina E. ;

Mullen, Michael T. ;

Kirschen, Matthew P. ;

Bastian, Rachel A. ;

Dowling, Michael M. ;

Lo, Warren ;

Jordan, Lori C. ;

Bernard, Timothy J. ;

Friedman, Neil ;

deVeber, Gabrielle ;

Kirton, Adam ;

Abraham, Lisa ;

Licht, Daniel J. ;

Jawad, Abbas F. ;

Ellenberg, Jonas H. ;

Lautenbach, Ebbing ;

Ichord, Rebecca N. .

STROKE, 2012, 43 (02) :341-345

[6] Diagnostic pitfalls in paediatric ischaemic stroke [J].

Braun, Kees P. J. ;

Kappelle, L. Jaap ;

Kirkham, Fenella J. ;

DeVeber, Gabrielle .

DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY, 2006, 48 (12) :985-990

[7] Interrater Reliability of the Pediatric National Institutes of Health Stroke Scale (PedNIHSS) in a Multicenter Study [J].

Ichord, Rebecca N. ;

Bastian, Rachel ;

Abraham, Lisa ;

Askalan, Rand ;

Benedict, Susan ;

Bernard, Timothy J. ;

Beslow, Lauren ;

deVeber, Gabrielle ;

Dowling, Michael ;

Friedman, Neil ;

Fullerton, Heather ;

Jordan, Lori ;

Kan, Li ;

Kirton, Adam ;

Amlie-Lefond, Catherine ;

Licht, Daniel ;

Lo, Warren ;

McClure, Chalmer ;

Pavlakis, Steve ;

Smith, Sabrina E. ;

Tan, Marilyn ;

Kasner, Scott ;

Jawad, Abbas F. .

STROKE, 2011, 42 (03) :613-617

[8] Thrombolysis for ischemic stroke in children - Data from the nationwide inpatient sample [J].

Janjua, Nazli ;

Nasar, Abu ;

Lynch, John K. ;

Qureshi, Adnan I. .

STROKE, 2007, 38 (06) :1850-1854

[9] Guidelines for the Early Management of Patients With Acute Ischemic Stroke A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association [J].

Jauch, Edward C. ;

Saver, Jeffrey L. ;

Adams, Harold P., Jr. ;

Bruno, Askiel ;

Connors, J. J. ;

Demaerschalk, Bart M. ;

Khatri, Pooja ;

McMullan, Paul W., Jr. ;

Qureshi, Adnan I. ;

Rosenfield, Kenneth ;

Scott, Phillip A. ;

Summers, Debbie R. ;

Wang, David Z. ;

Wintermark, Max ;

Yonas, Howard .

STROKE, 2013, 44 (03) :870-947

[10] Metrics for Measuring Quality of Care in Comprehensive Stroke Centers: Detailed Follow-Up to Brain Attack Coalition Comprehensive Stroke Center Recommendations A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association [J].

Leifer, Dana ;

Bravata, Dawn M. ;

Connors, J. J. , III ;

Hinchey, Judith A. ;

Jauch, Edward C. ;

Johnston, S. Claiborne ;

Latchaw, Richard ;

Likosky, William ;

Ogilvy, Christopher ;

Qureshi, Adnan I. ;

Summers, Debbie ;

Sung, Gene Y. ;

Williams, Linda S. ;

Zorowitz, Richard .

STROKE, 2011, 42 (03) :849-877

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