Micellar-System-Mediated Direct Fluorination of Ketones in Water

被引：44
作者：
Stavber, Gaj [2 ]
Zupan, Marko [2 ]
Stavber, Stojan [1 ]
机构：
[1] Jozef Stefan Inst, Organ & Bioorgan Chem Lab, Ljubljana 1000, Slovenia
[2] Univ Ljubljana, Fac Chem & Chem Technol, Ljubljana 1000, Slovenia
来源：
SYNLETT | 2009年 / 04期
关键词：
ketones; halogenation; micelles; F-TEDA-BF4; water; SODIUM DODECYL-SULFATE; HYDROGEN-PEROXIDE; ELECTROPHILIC FLUORINATION; MEDICINAL CHEMISTRY; ALPHA-FLUORINATION; ORGANIC-REACTIONS; SELECTFLUOR; BROMINATION; F-TEDA-BF4; SOLVENT;
D O I：
10.1055/s-0028-1087924
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A micellar system was developed and applied for direct regioselective fluorination of a variety of cyclic and acyclic ketones to alpha-fluoroketones in water as reaction medium with Selectflour F-TEDA-BF4 as fluorinating reagent. The inexpensive ionic amphiphile sodium dodecyl sulfate (SDS) was found to be all excellent promoter for fluorofunctionalization of hydrophobic ketones without prior activation or Use of acid catalysts.
引用
收藏
页码：589 / 594
页数：6
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