Sydnone Sulfonamide Derivatives as Antibacterial, Antifungal, Antiproliferative and Anti-HIV Agents

被引：13

作者：

Asundaria, Shahrukh T. ^{[1
]}

Pannecouque, Christophe ^{[2
]}

De Clercq, Erik ^{[2
]}

Patel, Keshav C. ^{[1
]}

机构：

[1] Veer Narmad South Gujarat Univ, Dept Chem, Surat 395007, Gujarat, India

[2] Katholieke Univ Leuven, Rega Inst Med Res, Leuven, Belgium

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2014年 / 48卷 / 04期

关键词：

anti-HIV; antiprolioferative; sydnone; sulfonamides; BIOLOGICAL EVALUATION; ANTITUMOR-ACTIVITY; ANALOGS; SUSCEPTIBILITY;

D O I：

10.1007/s11094-014-1090-y

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Three series of substituted sydnone sulfonamide derivatives were synthesized wherein 3-(4-methylphenyl)-4-(chlorosulfonyl)sydnone (5) was linked by a sulfonamide linkage with various thiazole, benzothiazole and quinazoline groups. The structures of the compounds were confirmed by IR and NMR spectroscopy and elemental analysis. The synthesized compounds were evaluated for their antibacterial, antifungal, antiproliferative and anti-HIV activities. Anti-HIV activity was determined against human immunodeficiency virus HIV-1 (III-B) and HIV-2 (ROD) in MT-4 cells. Inhibition of cytomegalovirus and varicella-zoster virus (VZV) replication was measured in human embryonic lung (HEL) cells.

引用

页码：260 / 268

页数：9

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