New system for peptide synthesis using N-acylpyrazoles

被引：2
|
作者：
Kashima, C [1 ]
Tsuruoka, S [1 ]
Mizuhara, S [1 ]
机构：
[1] Univ Tsukuba, Dept Chem, Tsukuba, Ibaraki 3058571, Japan
来源：
HETEROCYCLES | 2000年 / 52卷 / 01期
关键词：
D O I：
10.3987/COM-99-S51
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
New system of peptide synthesis was described. The extension of one amino acid unit on the peptide chain was constituted from only 2 reaction steps, the conversion from esters to the corresponding N-acylpyrazoles and the subsequent aminolysis with amino esters. This new system was distinctive from the conventional peptide synthesis, which was consisted of 3 steps of the deprotection, the activation and the condensation. Moreover, the key intermediate N-acylpyrazoles exhibited the excellent properties of high sensitivity and separability for the chiral column on HPLC using the UV detector.
引用
收藏
页码：413 / 424
页数：12
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