Time of Exercise Specifies the Impact on Muscle Metabolic Pathways and Systemic Energy Homeostasis

被引:206
作者
Sato, Shogo [1 ]
Basse, Astrid Linde [2 ]
Schonke, Milena [3 ]
Chen, Siwei [4 ]
Samad, Muntaha [4 ]
Altintas, Ali [2 ]
Laker, Rhianna C. [2 ]
Dalbram, Emilie [2 ]
Barres, Romain [2 ]
Baldi, Pierre [4 ]
Treebak, Jonas T. [2 ]
Zierath, Juleen R. [2 ,3 ,5 ]
Sassone-Corsi, Paolo [1 ]
机构
[1] Univ Calif Irvine, Dept Biol Chem, Sch Med, Ctr Epigenet & Metab,INSERM,U1233, Irvine, CA 92717 USA
[2] Univ Copenhagen, Novo Nordisk Fdn, Ctr Basic Metab Res, Sect Integrat Physiol, Copenhagen, Denmark
[3] Karolinska Inst, Dept Mol Med & Surg, Integrat Physiol, Stockholm, Sweden
[4] Univ Calif Irvine, Inst Genom & Bioinformat, Irvine, CA USA
[5] Karolinska Inst, Dept Physiol & Pharmacol, Integrat Physiol, Stockholm, Sweden
基金
美国国家卫生研究院; 瑞典研究理事会;
关键词
SKELETAL-MUSCLE; CIRCADIAN CLOCK; MOLECULAR REGULATION; DIFFERENTIAL EXPRESSION; GENE-EXPRESSION; ACETYL-COA; PPAR-DELTA; HYPOXIA; RHYTHMS; LIVER;
D O I
10.1016/j.cmet.2019.03.013
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
While the timing of food intake is important, it is unclear whether the effects of exercise on energy metabolism are restricted to unique time windows. As circadian regulation is key to controlling metabolism, understanding the impact of exercise performed at different times of the day is relevant for physiology and homeostasis. Using high-throughput transcriptomic and metabolomic approaches, we identify distinct responses of metabolic oscillations that characterize exercise in either the early rest phase or the early active phase in mice. Notably, glycolytic activation is specific to exercise at the active phase. At the molecular level, HIF1 alpha, a central regulator of glycolysis during hypoxia, is selectively activated in a time-dependent manner upon exercise, resulting in carbohydrate exhaustion, usage of alternative energy sources, and adaptation of systemic energy expenditure. Our findings demonstrate that the time of day is a critical factor to amplify the beneficial impact of exercise on both metabolic pathways within skeletal muscle and systemic energy homeostasis.
引用
收藏
页码:92 / +
页数:23
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