Dietary Flavonoids, CYP1A1 Genetic Variants, and the Risk of Colorectal Cancer in a Korean population

被引：24

作者：

Cho, Young Ae ^{[1
]}

Lee, Jeonghee ^{[1
]}

Oh, Jae Hwan ^{[2
]}

Chang, Hee Jin ^{[2
]}

Sohn, Dae Kyung ^{[2
]}

Shin, Aesun ^{[1
,3
]}

Kim, Jeongseon ^{[1
]}

机构：

[1] Natl Canc Ctr, Mol Epidemiol Branch, Goyang, South Korea

[2] Natl Canc Ctr, Ctr Colorectal Canc, Natl Canc Ctr Hosp, Goyang, South Korea

[3] Seoul Natl Univ, Dept Prevent Med, Coll Med, Seoul, South Korea

来源：

SCIENTIFIC REPORTS | 2017年 / 7卷

基金：

新加坡国家研究基金会;

关键词：

METABOLIZING-ENZYMES; CIGARETTE-SMOKING; POLYPHENOLS; POTENT; POLYMORPHISMS; ASSOCIATION; EXPRESSION; HEALTH; IMPACT;

D O I：

10.1038/s41598-017-00117-8

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The role of dietary flavonoid intake in colorectal carcinogenesis might differ according to flavonoid subclasses and individual genetic variants related to carcinogen metabolism. Therefore, we examined whether greater dietary intake of flavonoid subclasses was associated with a lower risk of colorectal cancer and whether CYP1A1 genetic variants altered this association. A semi-quantitative food frequency questionnaire was used to assess the dietary intake of six flavonoid subclasses (flavonols, flavones, flavanones, flavan-3-ols, anthocyanidins, and isoflavones) in 923 patients with colorectal cancer and 1,846 controls; furthermore, CYP1A1 genetic variants (rs4646903 and rs1048943) were genotyped. Among the subclasses of flavonoids, higher intake of flavonols and flavan-3-ols showed a stronger association with a reduced risk of colorectal cancer after adjusting for potential confounding factors. Carriers of the CYP1A1 rs4646903 CC homozygous variant showed a reduced risk of rectal cancer compared with that in TT carriers. The inverse association between dietary flavonol intake and colorectal cancer risk was stronger among carriers of the CC homozygous variant than among T allele carriers (P for interaction = 0.02), particularly for rectal cancer (P for interaction = 0.005). In conclusion, the effect of dietary flavonoid intake on colorectal cancer risk differs according to flavonoid subclasses and CYP1A1 genetic variants.

引用

页数：8

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