Identification of the glycoprotein IB/IX binding site in the VWF-A1 domain by molecular modelling and site specific mutagenesis.

被引:0
|
作者
Cruz, MA
Handin, RI
机构
[1] BRIGHAM & WOMENS HOSP,BOSTON,MA 02115
[2] HARVARD UNIV,SCH MED,BOSTON,MA
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:1268 / 1268
页数:1
相关论文
共 50 条
  • [41] Identification of a mutation in a GATA binding site of the platelet glycoprotein Ib beta promoter resulting in the Bernard-Soulier Syndrome
    Ludlow, LB
    Schick, BP
    Budarf, ML
    Driscoll, DA
    Zackai, EH
    Cohen, A
    Konkle, BA
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (36) : 22076 - 22080
  • [42] COMP 263-Identification of ligand binding site of urotensin-II receptor by site-directed mutagenesis and molecular modeling
    Li, Jian
    Qi, Jenson
    Almond, Harold R., Jr.
    Wang, Yuanping
    Minor, Lisa
    Kinney, William A.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2008, 236
  • [43] Targeting platelet-leukocyte interactions:: Identification of the integrin Mac-1 binding site for the platelet counter-receptor glycoprotein Ibα
    Ehlers, R
    Chen, ZP
    Ustinov, VA
    Lopez, JA
    Plow, EF
    Simon, DI
    CIRCULATION, 2002, 106 (19) : 145 - 145
  • [44] The binding site of alloantibody to von Willebrand factor which inhibits binding to glycoprotein Ib was localized in the amino-terminal flanking region of the A1 domain.
    Shibata, M
    Shima, M
    Fujimura, Y
    Takahashi, Y
    Nakai, H
    Sakurai, Y
    Asatani, M
    Nomura, A
    Take, H
    Yoshioka, A
    BLOOD, 1997, 90 (10) : 136 - 136
  • [45] Identification of a binding site for integrin αIIbβ3 in the von Willebrand factor (VWF) A1 domain:: Dual roles for the A1 domain in platelet thrombus formation.
    Chen, JM
    Cruz, MA
    López, JA
    BLOOD, 2004, 104 (11) : 995A - 995A
  • [46] The ligand binding site of NPY at the rat Y1 receptor investigated by site-directed mutagenesis and molecular modeling
    Robin-Jagerschmidt, C
    Sylte, I
    Bihoreau, C
    Hendricksen, L
    Calvet, A
    Dahl, SG
    Bénicourt, C
    MOLECULAR AND CELLULAR ENDOCRINOLOGY, 1998, 139 (1-2) : 187 - 198
  • [47] Identification of critical residues for ligand binding in the integrin β3 I-domain by site-directed mutagenesis
    Yamanouchi, J
    Hato, T
    Tamura, T
    Fujita, S
    THROMBOSIS AND HAEMOSTASIS, 2002, 87 (04) : 756 - 762
  • [48] STRUCTURAL AND FUNCTIONAL-ROLE OF THE CARBOHYDRATE SIDE-CHAINS WITHIN THE GLYCOPROTEIN-IB BINDING DOMAIN OF VON-WILLEBRAND-FACTOR ANALYZED BY SITE-DIRECTED MUTAGENESIS
    HAYASHI, T
    RUGGERI, ZM
    WARE, J
    THROMBOSIS AND HAEMOSTASIS, 1993, 69 (06) : 979 - 979
  • [49] Site-specific characterization of SARS-CoV-2 spike glycoprotein receptor-binding domain
    Antonopoulos, Aristotelis
    Broome, Steven
    Sharov, Victor
    Ziegenfuss, Christopher
    Easton, Richard L.
    Panico, Maria
    Dell, Anne
    Morris, Howard R.
    Haslam, Stuart M.
    GLYCOBIOLOGY, 2021, 31 (03) : 181 - 187
  • [50] Identification of the primary collagen-binding surface on human glycoprotein VI by site-directed mutagenesis and by a blocking phage antibody
    Smethurst, PA
    Joutsi-Korhonen, L
    O'Connor, MN
    Wilson, E
    Jennings, NS
    Garner, SF
    Zhang, YJ
    Knight, CG
    Dafforn, TR
    Buckle, A
    Ijsseldijk, MJW
    de Groot, PG
    Watkins, NA
    Farndale, RW
    Ouwehand, WH
    BLOOD, 2004, 103 (03) : 903 - 911