Virus-Mimetic Cytoplasm-Cleavable Magnetic/Silica Nanoclusters for Enhanced Gene Delivery to Mesenchymal Stem Cells

被引：73
作者：
Gandra, Naveen [1 ]
Wang, Dong-Dong [1 ]
Zhu, Ye [1 ]
Mao, Chuanbin [1 ]
机构：
[1] Univ Oklahoma, Dept Chem & Biochem, Stephenson Life Sci Res Ctr, Norman, OK 73019 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 43期
基金：
美国国家科学基金会; 美国国家卫生研究院;
关键词：
gene delivery; nanoparticles; phage display; stem cells; virus mimetics; TARGETING PEPTIDES; IN-VIVO; NANOPARTICLES; THERAPY; VECTOR; SYSTEM; COAT; RAT;
D O I：
10.1002/anie.201301113
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
It does get in: Phage is made of DNA as a core and protein as a coat, and it can transfer DNA into host cells with high efficiency. Phage-mimetic gene transfer to hard-to-transfect mesenchymal stem cells (MSCs) was achieved using virus-mimetic magnetic silica nanoclusters (VMSNCs). The VMSNCs bear MSC-homing phage-borne protein on the surface and encapsulate DNA inside, promoting the transfer of DNA into MSCs. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：11278 / 11281
页数：4
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