Virus-Mimetic Cytoplasm-Cleavable Magnetic/Silica Nanoclusters for Enhanced Gene Delivery to Mesenchymal Stem Cells

被引：73

作者：

Gandra, Naveen ^{[1
]}

Wang, Dong-Dong ^{[1
]}

Zhu, Ye ^{[1
]}

Mao, Chuanbin ^{[1
]}

机构：

[1] Univ Oklahoma, Dept Chem & Biochem, Stephenson Life Sci Res Ctr, Norman, OK 73019 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 43期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

gene delivery; nanoparticles; phage display; stem cells; virus mimetics; TARGETING PEPTIDES; IN-VIVO; NANOPARTICLES; THERAPY; VECTOR; SYSTEM; COAT; RAT;

D O I：

10.1002/anie.201301113

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

It does get in: Phage is made of DNA as a core and protein as a coat, and it can transfer DNA into host cells with high efficiency. Phage-mimetic gene transfer to hard-to-transfect mesenchymal stem cells (MSCs) was achieved using virus-mimetic magnetic silica nanoclusters (VMSNCs). The VMSNCs bear MSC-homing phage-borne protein on the surface and encapsulate DNA inside, promoting the transfer of DNA into MSCs. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：11278 / 11281

页数：4

共 26 条

[1] Evolutionary Selection of New Breast Cancer Cell-Targeting Peptides and Phages with the Cell-Targeting Peptides Fully Displayed on the Major Coat and Their Effects on Actin Dynamics during Cell Internalization [J].

Abbineni, Gopal ;

Modali, Sita ;

Safiejko-Mroczka, Barbara ;

Petrenko, Valery A. ;

Mao, Chuanbin .

MOLECULAR PHARMACEUTICS, 2010, 7 (05) :1629-1642

[2] Polyethyleneimine-mediated gene delivery into human adipose derived stem cells [J].

Ahn, Hyun Hee ;

Lee, Jung Hwa ;

Kim, Kyung Sook ;

Lee, Ju Young ;

Kim, Moon Suk ;

Khang, Gilson ;

Lee, Il Woo ;

Lee, Hai Bang .

BIOMATERIALS, 2008, 29 (15) :2415-2422

[3] Toward delivery of multiple growth factors in tissue engineering [J].

Chen, Fa-Ming ;

Zhang, Min ;

Wu, Zhi-Fen .

BIOMATERIALS, 2010, 31 (24) :6279-6308

[4] Characterization of aqueous dispersions of Fe3O4 nanoparticles and their biomedical applications [J].

Cheng, FY ;

Su, CH ;

Yang, YS ;

Yeh, CS ;

Tsai, CY ;

Wu, CL ;

Wu, MT ;

Shieh, DB .

BIOMATERIALS, 2005, 26 (07) :729-738

[5] Glutathione-responsive nano-vehicles as a promising platform for targeted intracellular drug and gene delivery [J].

Cheng, Ru ;

Feng, Fang ;

Meng, Fenghua ;

Deng, Chao ;

Feijen, Jan ;

Zhong, Zhiyuan .

JOURNAL OF CONTROLLED RELEASE, 2011, 152 (01) :2-12

[6] Cationic lipid-DNA complexes in gene delivery:: from biophysics to biological applications [J].

de Lima, MCP ;

Simoes, S ;

Pires, P ;

Faneca, H ;

Düzgünes, N .

ADVANCED DRUG DELIVERY REVIEWS, 2001, 47 (2-3) :277-294

[7] Gene therapy progress and prospects: magnetic nanoparticle-based gene delivery [J].

Dobson, J .

GENE THERAPY, 2006, 13 (04) :283-287

[8] TISSUE SULFHYDRYL GROUPS [J].

ELLMAN, GL .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1959, 82 (01) :70-77

[9] Bacteriophage Bionanowire as a Carrier for Both Cancer-Targeting Peptides and Photosensitizers and its use in Selective Cancer Cell Killing by Photodynamic Therapy [J].

Gandra, Naveen ;

Abbineni, Gopal ;

Qu, Xuewei ;

Huai, Yanyan ;

Wang, Li ;

Mao, Chuanbin .

SMALL, 2013, 9 (02) :215-221

[10] A simplified system for generating recombinant adenoviruses [J].

He, TC ;

Zhou, SB ;

da Costa, LT ;

Yu, J ;

Kinzler, KW ;

Vogelstein, B .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (05) :2509-2514

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