Virus-Mimetic Cytoplasm-Cleavable Magnetic/Silica Nanoclusters for Enhanced Gene Delivery to Mesenchymal Stem Cells

被引：72
作者：
Gandra, Naveen [1 ]
Wang, Dong-Dong [1 ]
Zhu, Ye [1 ]
Mao, Chuanbin [1 ]
机构：
[1] Univ Oklahoma, Dept Chem & Biochem, Stephenson Life Sci Res Ctr, Norman, OK 73019 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 43期
基金：
美国国家科学基金会; 美国国家卫生研究院;
关键词：
gene delivery; nanoparticles; phage display; stem cells; virus mimetics; TARGETING PEPTIDES; IN-VIVO; NANOPARTICLES; THERAPY; VECTOR; SYSTEM; COAT; RAT;
D O I：
10.1002/anie.201301113
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
It does get in: Phage is made of DNA as a core and protein as a coat, and it can transfer DNA into host cells with high efficiency. Phage-mimetic gene transfer to hard-to-transfect mesenchymal stem cells (MSCs) was achieved using virus-mimetic magnetic silica nanoclusters (VMSNCs). The VMSNCs bear MSC-homing phage-borne protein on the surface and encapsulate DNA inside, promoting the transfer of DNA into MSCs. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：11278 / 11281
页数：4
相关论文
共 26 条
  • [1] Evolutionary Selection of New Breast Cancer Cell-Targeting Peptides and Phages with the Cell-Targeting Peptides Fully Displayed on the Major Coat and Their Effects on Actin Dynamics during Cell Internalization
    Abbineni, Gopal
    Modali, Sita
    Safiejko-Mroczka, Barbara
    Petrenko, Valery A.
    Mao, Chuanbin
    [J]. MOLECULAR PHARMACEUTICS, 2010, 7 (05) : 1629 - 1642
  • [2] Polyethyleneimine-mediated gene delivery into human adipose derived stem cells
    Ahn, Hyun Hee
    Lee, Jung Hwa
    Kim, Kyung Sook
    Lee, Ju Young
    Kim, Moon Suk
    Khang, Gilson
    Lee, Il Woo
    Lee, Hai Bang
    [J]. BIOMATERIALS, 2008, 29 (15) : 2415 - 2422
  • [3] Toward delivery of multiple growth factors in tissue engineering
    Chen, Fa-Ming
    Zhang, Min
    Wu, Zhi-Fen
    [J]. BIOMATERIALS, 2010, 31 (24) : 6279 - 6308
  • [4] Characterization of aqueous dispersions of Fe3O4 nanoparticles and their biomedical applications
    Cheng, FY
    Su, CH
    Yang, YS
    Yeh, CS
    Tsai, CY
    Wu, CL
    Wu, MT
    Shieh, DB
    [J]. BIOMATERIALS, 2005, 26 (07) : 729 - 738
  • [5] Glutathione-responsive nano-vehicles as a promising platform for targeted intracellular drug and gene delivery
    Cheng, Ru
    Feng, Fang
    Meng, Fenghua
    Deng, Chao
    Feijen, Jan
    Zhong, Zhiyuan
    [J]. JOURNAL OF CONTROLLED RELEASE, 2011, 152 (01) : 2 - 12
  • [6] Cationic lipid-DNA complexes in gene delivery:: from biophysics to biological applications
    de Lima, MCP
    Simoes, S
    Pires, P
    Faneca, H
    Düzgünes, N
    [J]. ADVANCED DRUG DELIVERY REVIEWS, 2001, 47 (2-3) : 277 - 294
  • [7] Gene therapy progress and prospects: magnetic nanoparticle-based gene delivery
    Dobson, J
    [J]. GENE THERAPY, 2006, 13 (04) : 283 - 287
  • [8] TISSUE SULFHYDRYL GROUPS
    ELLMAN, GL
    [J]. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1959, 82 (01) : 70 - 77
  • [9] Bacteriophage Bionanowire as a Carrier for Both Cancer-Targeting Peptides and Photosensitizers and its use in Selective Cancer Cell Killing by Photodynamic Therapy
    Gandra, Naveen
    Abbineni, Gopal
    Qu, Xuewei
    Huai, Yanyan
    Wang, Li
    Mao, Chuanbin
    [J]. SMALL, 2013, 9 (02) : 215 - 221
  • [10] A simplified system for generating recombinant adenoviruses
    He, TC
    Zhou, SB
    da Costa, LT
    Yu, J
    Kinzler, KW
    Vogelstein, B
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (05) : 2509 - 2514
123