Apop-1 Induces caspase-dependent Apoptosis

被引：0
|
作者：
Sun, Xin [1 ]
Lv, Gang [1 ]
Gao, Ling [1 ]
Kong, Fanli [1 ]
Zhu, Xiaotao [2 ]
Tian, Dan [1 ]
Tong, Haibin [1 ]
Chu, Xiaodan [1 ]
Xie, Yu
机构：
[1] Beihua Univ China, Life Sci Ctr, Jilin, Jilin, Peoples R China
[2] Cent Hosp Jilin, Dept Surg, Jilin, Jilin, Peoples R China
来源：
2010 4TH INTERNATIONAL CONFERENCE ON BIOINFORMATICS AND BIOMEDICAL ENGINEERING (ICBBE 2010) | 2010年
关键词：
Apop-1; VSMC; Apoptosis; SMOOTH-MUSCLE-CELLS; ATHEROSCLEROTIC PLAQUES; CYTOCHROME-C; MITOCHONDRIA; RELEASE; DEATH;
D O I：
暂无
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Apoptosis is a form of genetically programmed cell death, which plays a pivotal role in normal development and the maintenance of homeostasis of a variety of tissues including cardiovascular system. Apop-1 is a soluble protein consisting of 194 amino acids with a mitochondrial localization signal at its N-terminus. RT-PCR data revealed that Apop-1 is expressed in all the organs tested. Immunofluorescence study showed that Apop-1 protein is localized in mitochondria. Transient transfection experiment showed Apop-1 induces apoptosis of cultured VSMC, and this apoptosis is inhibited by a pan-caspase inhibitor Z-VAD. The apoptosis induced by Apop-1 may contribute to the loss of VSMC in atherosclerosis, which will influence the stability of atherosclerotic plaques.
引用
收藏
页数：4
相关论文
共 50 条
  • [1] Apop-1 induces apoptosis of cultured smooth muscle cells
    Sun, Xin
    Zhu, Xiaotao
    Pei, Yuhong
    Gao, Ling
    Kuan, Cheng
    Feng, Kai
    INTERNATIONAL JOURNAL OF CARDIOLOGY, 2007, 122 : 33 - 33
  • [2] Apop-1, a novel gene, inducing cyclophilin D-dependent apoptosis
    Yasuda, Osamu
    Fukuo, Keisuke
    Higuchi, Masayoshi
    Yotsui, Takamori
    Rakugi, Hiromi
    Ogihara, Toshio
    JOURNAL OF HYPERTENSION, 2006, 24 : 38 - 38
  • [3] Motexafin gadolinium induces mitochondriallymediated caspase-dependent apoptosis
    J. Chen
    J. Ramos
    M. Sirisawad
    R. Miller
    L. Naumovski
    Apoptosis, 2005, 10 : 1131 - 1142
  • [4] Clausenidin induces caspase-dependent apoptosis in colon cancer
    Waziri, Peter M.
    Abdullah, Rasedee
    Yeap, Swee Keong
    Omar, Abdul Rahman
    Kassim, Nur Kartinee
    Malami, Ibrahim
    How, Chee Wun
    Etti, Imaobong Christopher
    Ladidi, Mary Abu
    BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2016, 16
  • [5] Clausenidin induces caspase-dependent apoptosis in colon cancer
    Peter M. Waziri
    Rasedee Abdullah
    Swee Keong Yeap
    Abdul Rahman Omar
    Nur Kartinee Kassim
    Ibrahim Malami
    Chee Wun How
    Imaobong Christopher Etti
    Mary Ladidi Abu
    BMC Complementary and Alternative Medicine, 16
  • [6] Baculovirus IAP1 induces caspase-dependent apoptosis in insect cells
    Ikeda, Motoko
    Yamada, Hayato
    Ito, Hiroyuki
    Kobayashi, Michihiro
    JOURNAL OF GENERAL VIROLOGY, 2011, 92 : 2654 - 2663
  • [7] Diosmin induces caspase-dependent apoptosis in human glioblastoma cells
    Soares, Juliana M.
    De Faria, Bruna M.
    Ascari, Lucas M.
    Alves-Leon, Soniza, V
    De Souza, Jorge M.
    Soares, Antonio G.
    Cordeiro, Yraima
    Romao, Luciana F.
    ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS, 2019, 91 (04):
  • [8] Microinjection of cathepsin D induces caspase-dependent apoptosis in fibroblasts
    Roberg, K
    Kågedal, K
    Öllinger, K
    AMERICAN JOURNAL OF PATHOLOGY, 2002, 161 (01): : 89 - 96
  • [9] Caspase-dependent apoptosis in yeast
    Mazzoni, Cristina
    Falcone, Claudio
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2008, 1783 (07): : 1320 - 1327
  • [10] STUDY ON THE APOPTOTIC PROTEIN OF APOP-1
    Sun Xin
    Lv Gang
    Tian Dan
    Guan Xingang
    HEART, 2011, 97
12345