Ruthenium(II)-catalyzed reductive N-O bond cleavage of N-OR (R = H, alkyl, or acyl) substituted amides and sulfonamides

被引：12

作者：

You, Tingjie ^{[1
]}

Zhang, Maosheng ^{[1
]}

Chen, Jianhui ^{[1
]}

Liu, Hongmei ^{[1
]}

Xia, Yuanzhi ^{[1
]}

机构：

[1] Wenzhou Univ, Coll Chem & Mat Engn, Wenzhou 325035, Peoples R China

来源：

ORGANIC CHEMISTRY FRONTIERS | 2021年 / 8卷 / 01期

关键词：

ASYMMETRIC TRANSFER HYDROGENATION; CATALYZED TRANSFER HYDROGENATION; ENANTIOSELECTIVE TRANSFER HYDROGENATION; CHIRAL CYCLOPENTADIENYL LIGANDS; TRANSFER SEMIHYDROGENATION; ACTIVATION/CYCLOADDITION REACTIONS; STEREOSELECTIVE-SYNTHESIS; CARBENE COMPLEXES; IRON CATALYSTS; WEINREB AMIDES;

D O I：

10.1039/d0qo01093f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

With a commercially available ruthenium(II) catalyst and a mixture of HCOOH/NEt3 as the hydride source under an air atmosphere, a convenient method for the reductive cleavage of N-O bonds was described. This catalytic system was applicable for a variety of N-oxygen-substituted amides, as well as N-alkoxy sulfonamides, efficiently delivering the corresponding amide or primary sulfonamide products with good functional group tolerance in moderate to good yields.

引用

页码：112 / 119

页数：8

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