QSAR study on carbonic anhydrase inhibitors: aromatic/heterocyclic sulfonamides containing 8-quinoline-sulfonyl moieties, with topical activity as antiglaucoma agents

被引：44
作者：
Agrawal, VK
Bano, S
Supuran, C
Khadikar, PV
机构：
[1] Laxmi Fumigat & Pest Control Pvt Ltd, Div Res, Indore 452007, India
[2] Univ Florence, Dipartimento Chim, Lab Chim Bioinorgan, I-50019 Sesto Fiorentino, Italy
[3] APS Univ, QSAR & Comp Chem Labs, Rewa 486003, India
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2004年 / 39卷 / 07期
关键词：
QSAR; carbonic anhydrase inhibitors; valence connectivity; regression analysis; aromatic; hetrocyclic sulfonamides;
D O I：
10.1016/j.ejmech.2004.03.002
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Quantitative structure-activity-relation ship (QSAR) study on aromatic/heterocyclic sulfonamides containing 8-quinoline-sulfonyl carbonic anhydrase (CA) inhibitors has been carried out topologically using first-order valence connectivity index ((1)chi(v)). Excellent results are obtained against all the three isozymes; CA I, II and IV of the zinc enzyme CA by using indicator parameters along with (1)chi(v). (C) 2004 Elsevier SAS. All rights reserved.
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页码：593 / 600
页数：8
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