Recent advances in LDH-based nanosystems for cancer therapy

被引：43
作者：
Wen, Jia [1 ]
Yang, Kui [2 ]
Huang, Jie [1 ]
Sun, Shiguo [3 ]
机构：
[1] Hebei Univ, Inst Life Sci & Green Dev, Coll Pharmaceut Sci, Key Lab Pharmaceut Qual Control Hebei Prov, Baoding 071002, Peoples R China
[2] Hebei Univ, Coll Chem & Environm Sci, Key Lab Chem Biol Hebei Prov, Lab Med Chem & Mol Diag,Minist Educ, Baoding 071002, Peoples R China
[3] Hebei Univ Sci & Technol, Coll Chem & Pharmaceut Engn, Shijiazhuang 050018, Hebei, Peoples R China
来源：
MATERIALS & DESIGN | 2021年 / 198卷
基金：
中国国家自然科学基金;
关键词：
Layered double hydroxide; Chemotherapy; Phototiierapy; Gene therapy; immunotherapy; Combination therapy; LAYERED DOUBLE HYDROXIDE; DRUG-DELIVERY-SYSTEM; ANTIBACTERIAL ACTIVITY; PHOTODYNAMIC THERAPY; CONTROLLED-RELEASE; CARBOXYMETHYL CELLULOSE; ANTICANCER DRUGS; FACILE SYNTHESIS; CO-DELIVERY; IN-VITRO;
D O I：
10.1016/j.matdes.2020.109298
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
Cancer has become one of the greatest causes of death around the world. The treatment of cancer still remains a great problem. With recent advances made in the field of nanotechnology, layered double hydroxide (LDH)-based nanosystems have drawn special attention because of their good biocompatibility, pH-dependent biodegradability, anion exchange capacity, easy surface modification and high chemical stability, giving rise to great potential for cancer therapy. In the past decade, LDH-based nanosystems have been constructed for various cancer therapies. However, few review articles have described these important and promising achievements to promote the further development of LDH and its nanocomposites. This review aims to provide a comprehensive overview on the recent developments in LDH and its nanocomposites as powerful nanosystems for diverse cancer therapies, which is divided into five parts: chemotherapy, phototherapy, gene therapy, immunotherapy and combination therapy. This review also outlines future perspectives and current challenges in LDH and its nanocomposites for cancer therapy. (C) 2020 The Authors. Published by Elsevier Ltd.
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页数：13
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