IL-9 and Mast Cells Are Key Players of Candida albicans Commensalism and Pathogenesis in the Gut

被引：55

作者：

Renga, Giorgia ^{[1
]}

Moretti, Silvia ^{[1
]}

Oikonomou, Vasilis ^{[1
]}

Borghi, Monica ^{[1
]}

Zelante, Teresa ^{[1
]}

Paolicelli, Giuseppe ^{[1
]}

Costantini, Claudio ^{[1
]}

De Zuani, Marco ^{[2
]}

Villella, Valeria Rachela ^{[3
]}

Raia, Valeria ^{[4
]}

Del Sordo, Rachele ^{[1
]}

Bartoli, Andrea ^{[1
]}

Baldoni, Monia ^{[5
]}

Renauld, Jean-Christophe ^{[6
]}

Sidoni, Angelo ^{[1
]}

Garaci, Enrico ^{[7
,8
]}

Maiuri, Luigi ^{[3
,9
]}

Pucillo, Carlo ^{[2
]}

Romani, Luigina ^{[1
]}

机构：

[1] Univ Perugia, Dept Expt Med, I-06132 Perugia, Italy

[2] Univ Udine, Dept Med & Biol Sci, I-33100 Udine, Italy

[3] Ist Sci San Raffaele, Div Genet & Cell Biol, European Inst Res Cyst Fibrosis, I-20132 Milan, Italy

[4] Federico II Univ Naples, Dept Translat Med Sci, Pediat Unit, Reg Cyst Fibrosis Ctr, I-80131 Naples, Italy

[5] Univ Perugia, Dept Med, I-06132 Perugia, Italy

[6] Ludwig Inst Canc Res, Brussels Branch, B-1200 Brussels, Belgium

[7] Telemat Univ, IRCCS, San Raffaele Pisana, I-00163 Rome, Italy

[8] Univ Tor Vergata, I-00163 Rome, Italy

[9] Univ Piemonte Orientale, Dept Hlth Sci, I-28100 Novara, Italy

来源：

CELL REPORTS | 2018年 / 23卷 / 06期

基金：

欧洲研究理事会;

关键词：

REGULATORY T-CELLS; ADAPTIVE IMMUNITY; DENDRITIC CELLS; CELIAC-DISEASE; TH9; CELLS; FOOD ALLERGY; TOLERANCE; DIFFERENTIATION; INFLAMMATION; INDUCTION;

D O I：

10.1016/j.celrep.2018.04.034

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Candida albicans is implicated in intestinal diseases. Identifying host signatures that discriminate between the pathogenic versus commensal nature of this human commensal is clinically relevant. In the present study, we identify IL-9 and mast cells (MCs) as key players of Candida commensalism and pathogenicity. By inducing TGF-beta in stromal MCs, IL-9 pivotally contributes to mucosal immune tolerance via the indoleamine 2,3-dioxygenase enzyme. However, Candida-driven IL-9 and mucosal MCs also contribute to barrier function loss, dissemination, and inflammation in experimental leaky gut models and are upregulated in patients with celiac disease. Inflammatory dysbiosis occurs with IL-9 and MC deficiency, indicating that the activity of IL-9 and MCs may go beyond host immunity to include regulation of the microbiota. Thus, the output of the IL-9/MC axis is highly contextual during Candida colonization and reveals how host immunity and the microbiota finely tune Candida behavior in the gut.

引用

页码：1767 / 1778

页数：12

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