Obesity and renal cell carcinoma: epidemiology, underlying mechanisms and management considerations

被引：25
作者：
Klinghoffer, Zachary [1 ]
Yang, Brian [1 ]
Kapoor, Anil [1 ]
Pinthus, Jehonathan H. [1 ]
机构：
[1] McMaster Univ, Dept Surg, Div Urol, Hamilton, ON L8S 4L8, Canada
来源：
EXPERT REVIEW OF ANTICANCER THERAPY | 2009年 / 9卷 / 07期
关键词：
adipokines; adiponectin; adipose tissue; BMI; IL-6; kidney cancer; leptin; nephrectomy; obesity; renal cell carcinoma; BODY-MASS INDEX; C-REACTIVE-PROTEIN; LAPAROSCOPIC RADICAL NEPHRECTOMY; FACTOR-TARGETED THERAPY; GROWTH-FACTOR-I; PLASMA ADIPONECTIN LEVELS; SINGLE-CENTER EXPERIENCE; LIVING KIDNEY DONORS; LONG-TERM OUTCOMES; BREAST-CANCER RISK;
D O I：
10.1586/ERA.09.51
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The incidence of both renal cell carcinoma (RCC) and obesity are steadily rising in Western societies. Recent studies have established that obesity is a significant risk factor for the development of several malignancies, including RCC. However, the mechanisms underlying this relationship remain to be fully elucidated. We review herein the epidemiological links between obesity and RCC, the potential mechanisms by which obesity can influence RCC development and progression, and the special considerations related to the treatment of obese patients with RCC.
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收藏
页码：975 / 987
页数：13
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