Cellular Mechanisms of Barrett's Esophagus Development

被引：10
作者：
Barbera, Mariagnese
Fitzgerald, Rebecca C. [1 ,2 ,3 ]
机构：
[1] Hutchison MRC Res Ctr, MRC Canc Cell Unit, Cambridge CB2 0XZ, England
[2] Addenbrookes Hosp, Dept Gastroenterol, Cambridge CB2 2QQ, England
[3] Addenbrookes Hosp, Dept Gen Med, Cambridge CB2 2QQ, England
来源：
SURGICAL ONCOLOGY CLINICS OF NORTH AMERICA | 2009年 / 18卷 / 03期
基金：
英国医学研究理事会;
关键词：
Metaplasia; Stem cells; GERD; Acid; Bile; GASTROESOPHAGEAL-REFLUX DISEASE; HOMEODOMAIN PROTEIN CDX2; PROTON PUMP INHIBITORS; NEOPLASTIC PROGRESSION; BILE-ACIDS; STEM-CELLS; SQUAMOUS EPITHELIUM; GENE-EXPRESSION; NITRIC-OXIDE; DNA-DAMAGE;
D O I：
10.1016/j.soc.2009.03.001
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Barrett's esophagus (BE) is a metaplastic premalignant disorder in which the normal stratified squamous epithelium of the lower esophagus is replaced by a columnar lined epithelium with intestinal differentiation. BE generally occurs in the context of chronic gastroesophageal reflux disease and it is the primary risk factor for the development of esophageal adenocarcinoma, with a conversion rate of 0.5% to 1% per annum. The dramatic increase of esophageal adenocarcinoma, incidence in the western world over the last two decades justifies the strong interest in BE and its development with the aim to improve preventative and therapeutic clinical strategies.
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收藏
页码：393 / +
页数：19
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