Mitochondrial Fusion: The Machineries In and Out

被引：255
作者：
Gao, Song [1 ,2 ]
Hu, Junjie [3 ]
机构：
[1] Sun Yat Sen Univ, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China, Canc Ctr, Guangzhou 510060, Peoples R China
[2] Guangzhou Regenerat Med & Hlth Guangdong Lab, Guangzhou 510530, Peoples R China
[3] Chinese Acad Sci, CAS Ctr Excellence Biomacromol, Inst Biophys, Natl Lab Biomacromol, Beijing 100101, Peoples R China
来源：
TRENDS IN CELL BIOLOGY | 2021年 / 31卷 / 01期
基金：
国家重点研发计划; 中国国家自然科学基金;
关键词：
DYNAMIN-RELATED PROTEIN; DOMINANT OPTIC ATROPHY; STRUCTURAL BASIS; GTP HYDROLYSIS; CRYSTAL-STRUCTURE; MEMBRANE-FUSION; PROVIDE INSIGHT; OPA1; FISSION; MFN1;
D O I：
10.1016/j.tcb.2020.09.008
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Mitochondria are highly dynamic organelles that constantly undergo fission and fusion. Disruption of mitochondrial dynamics undermines their function and causes several human diseases. The fusion of the outer (OMM) and inner mitochondrial membranes (IMM) is mediated by two classes of dynamin-like protein (DLP): mitofusin (MFN)/fuzzy onions 1 (Fzo1) and optic atrophy 1/mitochondria genome maintenance 1 (OPA1/Mgm1). Given the lack of structural information on these fusogens, the molecular mechanisms underlying mitochondrial fusion remain unclear, even after 20 years. Here, we review recent advances in structural studies of the mitochondrial fusion machinery, discuss their implication for DLPs, and summarize the pathogenic mechanisms of disease-causing mutations in mitochondrial fusion DLPs.
引用
收藏
页码：62 / 74
页数：13
相关论文
共 97 条
[1]   OPA1, encoding a dynamin-related GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28 [J].
Alexander, C ;
Votruba, M ;
Pesch, UEA ;
Thiselton, DL ;
Mayer, S ;
Moore, A ;
Rodriguez, M ;
Kellner, U ;
Leo-Kottler, B ;
Auburger, G ;
Bhattacharya, SS ;
Wissinger, B .
NATURE GENETICS, 2000, 26 (02) :211-215
[2]   Plasticity in salt bridge allows fusion-competent ubiquitylation of mitofusins and Cdc48 recognition [J].
Anton, Vincent ;
Buntenbroich, Ira ;
Schuster, Ramona ;
Babatz, Felix ;
Simoes, Tania ;
Altin, Selver ;
Calabrese, Gaetano ;
Riemer, Jan ;
Schauss, Astrid ;
Escobar-Henriques, Mafalda .
LIFE SCIENCE ALLIANCE, 2019, 2 (06)
[3]   Membrane fission by dynamin: what we know and what we need to know [J].
Antonny, Bruno ;
Burd, Christopher ;
De Camilli, Pietro ;
Chen, Elizabeth ;
Daumke, Oliver ;
Faelber, Katja ;
Ford, Marijn ;
Frolov, Vadim A. ;
Frost, Adam ;
Hinshaw, Jenny E. ;
Kirchhausen, Tom ;
Kozlov, Michael M. ;
Lenz, Martin ;
Low, Harry H. ;
McMahon, Harvey ;
Merrifield, Christien ;
Pollard, Thomas D. ;
Robinson, Phillip J. ;
Roux, Aurelien ;
Schmid, Sandra .
EMBO JOURNAL, 2016, 35 (21) :2270-2284
[4]   Molecular basis of selective mitochondrial fusion by heterotypic action between OPA1 and cardiolipin [J].
Ban, Tadato ;
Ishihara, Takaya ;
Kohno, Hiroto ;
Saita, Shotaro ;
Ichimura, Ayaka ;
Maenaka, Katsumi ;
Oka, Toshihiko ;
Mihara, Katsuyoshi ;
Ishihara, Naotada .
NATURE CELL BIOLOGY, 2017, 19 (07) :856-+
[5]   OPA1 disease alleles causing dominant optic atrophy have defects in cardiolipin-stimulated GTP hydrolysis and membrane tubulation [J].
Ban, Tadato ;
Heymann, Juergen A. W. ;
Song, Zhiyin ;
Hinshaw, Jenny E. ;
Chan, David C. .
HUMAN MOLECULAR GENETICS, 2010, 19 (11) :2113-2122
[6]   Structures of the atlastin GTPase provide insight into homotypic fusion of endoplasmic reticulum membranes [J].
Bian, Xin ;
Klemm, Robin W. ;
Liu, Tina Y. ;
Zhang, Miao ;
Sun, Sha ;
Sui, Xuewu ;
Liu, Xinqi ;
Rapoport, Tom A. ;
Hu, Junjie .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (10) :3976-3981
[7]   A mitofusin-dependent docking ring complex triggers mitochondrial fusion in vitro [J].
Brandt, Tobias ;
Cavellini, Laetitia ;
Kuehlbrandt, Werner ;
Cohen, Mickael M. .
ELIFE, 2016, 5
[8]   Structural basis for conformational switching and GTP loading of the large G protein atlastin [J].
Byrnes, Laura J. ;
Singh, Avtar ;
Szeto, Kylan ;
Benvin, Nicole M. ;
O'Donnell, John P. ;
Zipfel, Warren R. ;
Sondermann, Holger .
EMBO JOURNAL, 2013, 32 (03) :369-384
[9]   Structural basis for the nucleotide-dependent dimerization of the large G protein atlastin-1/SPG3A [J].
Byrnes, Laura J. ;
Sondermann, Holger .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (06) :2216-2221
[10]   MFN1 structures reveal nucleotide-triggered dimerization critical for mitochondrial fusion [J].
Cao, Yu-Lu ;
Meng, Shuxia ;
Chen, Yang ;
Feng, Jian-Xiong ;
Gu, Dong-Dong ;
Yu, Bing ;
Li, Yu-Jie ;
Yang, Jin-Yu ;
Liao, Shuang ;
Chan, David C. ;
Gao, Song .
NATURE, 2017, 542 (7641) :372-+
12345678910