Genetic susceptibility and gastric cancer risk: The importance of meta-analyses as a statistical tool

被引：9

作者：

Asuncion Garcia-Gonzalez, Maria ^{[1
,2
]}

Lanas, Angel ^{[1
,2
,3
,4
]}

机构：

[1] Inst Invest Sanit Aragon, Inst Aragones Ciencias Salud, Zaragoza, Spain

[2] Ciber Enfermedades Hepat Digest CIBERehd, Zaragoza, Spain

[3] Hosp Clin Univ, Serv Aparato Digest, Zaragoza, Spain

[4] Univ Zaragoza, Zaragoza, Spain

来源：

GASTROENTEROLOGIA Y HEPATOLOGIA | 2014年 / 37卷 / 07期

关键词：

Cancer; Stomach; Polymorphism; Meta-analysis; HELICOBACTER-PYLORI INFECTION; NECROSIS-FACTOR-ALPHA; PROMOTER POLYMORPHISM; FUNCTIONAL POLYMORPHISM; INTERLEUKIN-6; LEVELS; ASSOCIATION; CARCINOMA; ADENOCARCINOMA; INFLAMMATION; MULTICENTER;

D O I：

10.1016/j.gastrohep.2014.01.007

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Gastric cancer (GC) is a complex disease and a worldwide health burden due to its high prevalence and poor prognosis. A deeper knowledge of the factors involved in the development and progression of GC could help to identify subpopulations at risk that therefore require surveillance or early treatment strategies. Current research is based on the study of genetic variants that confer a higher risk of GC and their interactions with environmental exposure. Recently, meta-analysis has emerged as an important statistical method involving pooling of data from individual association studies to increase statistical power and obtain more conclusive results. Given the importance of chronic inflammation in the process of gastric carcinogenesis, the present article reviews the most recent meta-analyses of the contribution of cytokine gene polymorphisms to GC risk. (C) 2013 Elsevier Espana, S.L. and AEEH y AEG. All rights reserved.

引用

页码：421 / 426

页数：6

共 47 条

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