New cytotoxic cardenolide glycoside from the seeds of Cerbera manghas

被引：39

作者：

Cheenpracha, S

Karalai, C

Rat-A-Pa, Y

Ponglimanont, C ^{[1
]}

Chantrapromma, K

机构：

[1] Prince Songkla Univ, Fac Sci, Dept Chem, Songkhla 90112, Thailand

[2] Walailak Univ, Inst Sci, Nakhon Si Thammarat 80160, Thailand

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2004年 / 52卷 / 08期

关键词：

Cerbera manghas; Apocynaceae; cardenolide; cytotoxicity;

D O I：

10.1248/cpb.52.1023

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new cytotoxic cardenolide glycoside, 3beta-O-(2'-O-acetyl-alpha-L-thevetosyl)-14beta-hydroxy-7-en-5beta-card-20(22)-enolide, (7,8-dehydrocerberin), together with five known cardenolides, 17beta-neriifolin, deacetyltanghinin, tanghinin, cerberin and 2'-O-acetyl-cerleaside A were isolated from the seeds of Cerbera manghas L. Their structures were elucidated by 1D- and 2D-NMR techniques as well as UV, IR and mass spectral data. 7,8-Dehydrocerberin, deacetyltanghinin and tanghinin exhibited cytotoxic activities against oral human epidermoid carcinoma (KB), human breast cancer cell (BC) and human small cells lung cancer (NCI-H187).

引用

页码：1023 / 1025

页数：3

共 7 条

[1]

ABE F, 1977, CHEM PHARM BULL, V25, P2744

[2] Activity-guided isolation of constituents of Cerbera manghas with antiproliferative and antiestrogenic activities [J].