Optimal indication criteria for neoadjuvant chemotherapy in patients with resectable colorectal liver metastases

被引：30

作者：

Ichida, Hirofumi ^{[1
]}

Mise, Yoshihiro ^{[1
]}

Ito, Hiromichi ^{[1
]}

Ishizawa, Takeaki ^{[1
]}

Inoue, Yosuke ^{[1
]}

Takahashi, Yu ^{[1
]}

Shinozaki, Eiji ^{[2
]}

Yamaguchi, Kensei ^{[2
]}

Saiura, Akio ^{[1
]}

机构：

[1] Japanese Fdn Canc Res, Canc Inst Hosp, Dept Gastroenterol Surg, Koto Ku, 3-8-31 Ariake, Tokyo 1358550, Japan

[2] Japanese Fdn Canc Res, Canc Inst Hosp, Dept Gastroenterol, Koto Ku, 3-8-31 Ariake, Tokyo 1358550, Japan

来源：

WORLD JOURNAL OF SURGICAL ONCOLOGY | 2019年 / 17卷 / 1期

关键词：

Colorectal cancer; Liver metastases; Chemotherapy; Liver resection; PREOPERATIVE CHEMOTHERAPY; HEPATIC RESECTION; PERIOPERATIVE CHEMOTHERAPY; RAS MUTATIONS; ADJUVANT CHEMOTHERAPY; INCREASE MORBIDITY; SURGERY; CANCER; MORTALITY; SURVIVAL;

D O I：

10.1186/s12957-019-1641-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

BackgroundThere are no optimal indication criteria for neoadjuvant chemotherapy (NAC) in patients with resectable colorectal liver metastases (CLM). The aim of this study was to prospectively assess the survival benefit of selective NAC administration in this patient population based on tumor characteristics.MethodsBorderline resectable CLM (BR-CLM) were defined as four or more liver metastases, CLM larger than 5cm, or CLM with concomitant resectable extrahepatic metastases. From 2010 to 2015, NAC was administered to BR-CLM patients. Upfront surgery without NAC was performed to patients having clearly resectable CLM (less than 3 lesions, smaller than 5cm, and no extrahepatic metastases: CR-US group). Survival outcomes of the two groups were assessed.ResultsThe BR-NAC group comprised 73 patients and the CR-US group 172. All patients in the BR-NAC group underwent subsequent resection, as none showed disease progression or chemotherapy-associated liver damage. The 3- and 5-year overall survival rates of the CR-US group were 83.0% and 74.0%, while patients in the BR-NAC group had comparable 3-year and 5-year overall survivals (80.5% and 66.6%, P=0.397).ConclusionDefining BR-CLM based on tumor characteristics optimizes patient selection for NAC. Favorable overall survival can be achieved by upfront surgery in patients with clearly resectable CLM and by NAC in patients with BR-CLM.

引用

页数：9

共 38 条

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