Adiponectin promotes migration activities of endothelial progenitor cells via Cdc42/Rac1

被引：47
|
作者：
Nakamura, Nobuhisa
Naruse, Keiko [1 ,2 ]
Matsuki, Takashi
Hamada, Yoji [3 ]
Nakashima, Eitaro
Kamiya, Hideki
Matsubara, Tatsuaki [2 ]
Enomoto, Atsushi [4 ]
Takahashi, Masahide [4 ]
Oiso, Yutaka
Nakamura, Jiro
机构：
[1] Nagoya Univ, Dept Endocrinol & Diabet, Grad Sch Med, Showa Ku, Nagoya, Aichi 4668550, Japan
[2] Aichi Gakuin Univ, Sch Dent, Dept Internal Med, Nagoya, Aichi 464, Japan
[3] Nagoya Univ, Dept Metab Dis, Sch Med, Nagoya, Aichi 4668550, Japan
[4] Nagoya Univ, Dept Pathol, Grad Sch Med, Nagoya, Aichi 4668550, Japan
来源：
FEBS LETTERS | 2009年 / 583卷 / 15期
关键词：
Adiponectin; Endothelial progenitor cell; Migration; Cdc42; Rac1; TYPE-2; DIABETES-MELLITUS; ACTIVATED PROTEIN-KINASE; INSULIN-RESISTANCE; GLOBULAR ADIPONECTIN; THERAPEUTIC NEOVASCULARIZATION; STIMULATES ANGIOGENESIS; RHO-GTPASES; FOLLOW-UP; NUMBER; AKT;
D O I：
10.1016/j.febslet.2009.07.011
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Adiponectin has anti-atherosclerotic effects through its direct actions on vascular cells. The present study investigates the molecular mechanisms of adiponectin in the migration of endothelial progenitor cells (EPCs) which play an important role in neovascularization and re-endothelization. The phosphorylation of Akt and the activations of Cdc42 and Rac1 were significantly increased by adiponectin. Adiponectin increased the migration activity of EPCs, which was completely inhibited by a PI3-kinase inhibitor. siRNA of Cdc42 or Rac1 completely inhibited the adiponectin-induced migration, but siRNA of Akt had no effects, indicating that adiponectin promotes the migration activities of EPCs mainly through PI3-kinase/Cdc42/Rac1.
引用
收藏
页码：2457 / 2463
页数：7
相关论文
共 50 条
  • [31] Novel Activities of Select NSAID R-Enantiomers against Rac1 and Cdc42 GTPases
    Oprea, Tudor I.
    Sklar, Larry A.
    Agola, Jacob O.
    Guo, Yuna
    Silberberg, Melina
    Roxby, Joshua
    Vestling, Anna
    Romero, Elsa
    Surviladze, Zurab
    Murray-Krezan, Cristina
    Waller, Anna
    Ursu, Oleg
    Hudson, Laurie G.
    Wandinger-Ness, Angela
    PLOS ONE, 2015, 10 (11):
  • [32] Cdc42/Rac1 participates in the control of telomerase activity in human nasopharyngeal cancer cells
    Yeh, YM
    Pan, YT
    Wang, TCV
    CANCER LETTERS, 2005, 218 (02) : 207 - 213
  • [33] Docetaxel induces Rac1 and Cdc42 Rho GTPase activation in prostate cancer cells
    Lopez Gonzalez, Andrea Paola
    Colon Gonzalez, Jessica
    Maria Fuentes, Maria C. Santa
    Dharmawardhane, Surangani
    Diaz Osterman, Carlos J.
    CANCER RESEARCH, 2024, 84 (06)
  • [34] IQGAP3 promotes tumor cell migration and invasion via interactions with Cdc42, Rac1, RhoA and R-Ras, and is involved in cytokinesis
    Jinawath, Natini
    Furukawa, Yoichi
    Nakamura, Yusuke
    CANCER RESEARCH, 2006, 66 (08)
  • [35] Regulation of platelet Rac1 and Cdc42 activation through interaction with calmodulin
    Elsaraj, Sherif M.
    Bhullar, Rajinder P.
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2008, 1783 (05): : 770 - 778
  • [36] Identification of IQGAP as a putative target for the small GTPases, Cdc42 and Rac1
    Kuroda, S
    Fukata, M
    Kobayashi, K
    Nakafuku, M
    Nomura, N
    Iwamatsu, A
    Kaibuchi, K
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (38) : 23363 - 23367
  • [37] Fc receptor-mediated phagocytosis requires CDC42 and Rac1
    Massol, P
    Montcourrier, P
    Guillemot, JC
    Chavrier, P
    EMBO JOURNAL, 1998, 17 (21): : 6219 - 6229
  • [38] Requirements for both Rac1 and Cdc42 in membrane ruffling and phagocytosis in leukocytes
    Cox, D
    Chang, P
    Zhang, Q
    Reddy, PG
    Bokoch, GM
    Greenberg, S
    JOURNAL OF EXPERIMENTAL MEDICINE, 1997, 186 (09): : 1487 - 1494
  • [39] Mammalian Lens Placode Invagination Requires Cdc42, RhoA and Rac1
    Chauhan, B. K.
    DiSanza, A.
    Choi, S. -Y.
    Lou, M.
    Beggs, H. E.
    Scita, G.
    Zheng, Y.
    Lang, R. A.
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2010, 51 (13)
  • [40] Cdc42 promotes transendothelial migration of cancer cells through β1 integrin
    Reymond, Nicolas
    Im, Jae Hong
    Garg, Ritu
    Vega, Francisco M.
    d'Agua, Barbara Borda
    Riou, Philippe
    Cox, Susan
    Valderrama, Ferran
    Muschel, Ruth J.
    Ridley, Anne J.
    JOURNAL OF CELL BIOLOGY, 2012, 199 (04): : 653 - 668
12345