Design, synthesis, and biological activity evaluation of campthothecin-HAA-Norcantharidin conjugates as antitumor agents in vitro

被引：15
|
作者：
Wang, Xian H. [1 ]
Huang, Mei [2 ,3 ]
Zhao, Chang K. [1 ]
Li, Chan [4 ]
Xu, Lang [1 ]
机构：
[1] Zunyi Med Univ, Sch Pharm, Zunyi City, Guizhou, Peoples R China
[2] Zunyi Med Univ, Dept Pharmacol, Minist Educ, Zunyi City, Guizhou, Peoples R China
[3] Zunyi Med Univ, Key Lab Basic Pharmacol, Minist Educ, Zunyi City, Guizhou, Peoples R China
[4] Sun Yat Sen Univ, Sch Pharm, Guangzhou, Guangdong, Peoples R China
来源：
CHEMICAL BIOLOGY & DRUG DESIGN | 2019年 / 93卷 / 06期
关键词：
camptothecin; conjugate; hydroxyacetic acid; norcantharidin; pro-drug; CAMPTOTHECIN; CANTHARIDIN; PRODRUGS;
D O I：
10.1111/cbdd.13397
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Three components of Camptothecin, hydroxyacetic acid, and functionalized norcantharidins were constructed together to form a novel series of camptothecin derivatives in a good yield. The synthesized campthothecin-HAA-norcantharidin conjugate pro-drugs could suppress cancer cell growth in vitro. These conjugated pro-drug molecules possess therapeutic potential as novel bi-functional conjugates platforms for cancer treatment.
引用
收藏
页码：986 / 992
页数：7
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