Design, synthesis, and biological activity evaluation of campthothecin-HAA-Norcantharidin conjugates as antitumor agents in vitro

被引：16

作者：

Wang, Xian H. ^{[1
]}

Huang, Mei ^{[2
,3
]}

Zhao, Chang K. ^{[1
]}

Li, Chan ^{[4
]}

Xu, Lang ^{[1
]}

机构：

[1] Zunyi Med Univ, Sch Pharm, Zunyi City, Guizhou, Peoples R China

[2] Zunyi Med Univ, Dept Pharmacol, Minist Educ, Zunyi City, Guizhou, Peoples R China

[3] Zunyi Med Univ, Key Lab Basic Pharmacol, Minist Educ, Zunyi City, Guizhou, Peoples R China

[4] Sun Yat Sen Univ, Sch Pharm, Guangzhou, Guangdong, Peoples R China

来源：

CHEMICAL BIOLOGY & DRUG DESIGN | 2019年 / 93卷 / 06期

关键词：

camptothecin; conjugate; hydroxyacetic acid; norcantharidin; pro-drug; CAMPTOTHECIN; CANTHARIDIN; PRODRUGS;

D O I：

10.1111/cbdd.13397

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Three components of Camptothecin, hydroxyacetic acid, and functionalized norcantharidins were constructed together to form a novel series of camptothecin derivatives in a good yield. The synthesized campthothecin-HAA-norcantharidin conjugate pro-drugs could suppress cancer cell growth in vitro. These conjugated pro-drug molecules possess therapeutic potential as novel bi-functional conjugates platforms for cancer treatment.

引用

页码：986 / 992

页数：7

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