Nanocrystalline titanium dioxide and magnesium oxide in vitro dermal absorption in human skin

被引：19

作者：

van der Merwe, Deon ^{[1
]}

Tawde, Snehal

Pickrell, John A.

Erickson, Larry E. ^{[1
]}

机构：

[1] Kansas State Univ, Ctr Hazardous Substance Res, Manhattan, KS 66506 USA

来源：

CUTANEOUS AND OCULAR TOXICOLOGY | 2009年 / 28卷 / 02期

关键词：

Dermal absorption; metal oxides; nanocrystalline; titanium dioxide; magnesium oxide; ZINC-OXIDE; PENETRATION; NANOPARTICLES; PERMEABILITY; FORMULATION;

D O I：

10.1080/15569520902914926

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

The dermal absorption potential of a nanocrystalline magnesium oxide (MgO) and titanium dioxide (TiO2) mixture in dermatomed human skin was assessed in vitro using Bronaugh-type flow-through diffusion cells. Nanocrystalline material was applied to the skin surface at a dose rate of 50 mg/cm(2) as a dry powder, as a water suspension, and as a water/surfactant (sodium lauryl sulfate) suspension, for 8 hours. Dermal absorption of nanocrystalline MgO and TiO2 through human skin with intact, functional stratum corneum was not detectable under the conditions of this experiment.

引用

页码：78 / 82

页数：5

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