Electroacupuncture attenuates neuropathic pain after brachial plexus injury

被引：16
作者：
Zhang, Shenyu [1 ,2 ,3 ]
Tang, Hailiang [4 ]
Zhou, Junming [1 ,2 ,3 ]
Gu, Yudong [1 ,2 ,3 ]
机构：
[1] Fudan Univ, Huashan Hosp, Dept Hand Surg, Shanghai 200040, Peoples R China
[2] Minist Hlth, Key Lab Hand Reconstruct, Shanghai 200040, Peoples R China
[3] Shanghai Key Lab Peripheral Nerve & Microsurg, Shanghai 200040, Peoples R China
[4] Fudan Univ, Huashan Hosp, Dept Neurosurg, Shanghai 200040, Peoples R China
来源：
NEURAL REGENERATION RESEARCH | 2014年 / 9卷 / 14期
基金：
中国国家自然科学基金;
关键词：
nerve regeneration; peripheral nerve injury; brachial plexus injury; neuropathic pain; electroacupuncture; beta-endorphin; chronic neuropathic pain; brachial plexus avulsion; neural regeneration; SPINAL-CORD; AVULSION; BEHAVIOR; MODEL; RATS;
D O I：
10.4103/1673-5374.137589
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Electroacupuncture has traditionally been used to treat pain, but its effect on pain following brachial plexus injury is still unknown. In this study, rat models of an avulsion injury to the left brachial plexus root (associated with upper-limb chronic neuropathic pain) were given electroacupuncture stimulation at bilateral Quchi (LI11), Hegu (LI04), Zusanli (ST36) and Yanglingquan (GB34). After electroacupuncture therapy, chronic neuropathic pain in the rats' upper limbs was significantly attenuated. Immunofluorescence staining showed that the expression of beta-endorphins in the arcuate nucleus was significantly increased after therapy. Thus, experimental findings indicate that electroacupuncture can attenuate neuropathic pain after brachial plexus injury through upregulating beta-endorphin expression.
引用
收藏
页码：1365 / 1370
页数：6
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