Coenzyme Q10 supplementation during pregnancy reduces the risk of pre-eclampsia

被引：54

作者：

Teran, Enrique ^{[1
]}

Hernandez, Isabel ^{[1
]}

Nieto, Belen ^{[2
]}

Tavara, Rosio ^{[2
]}

Ocampo, Juan Emilio ^{[2
]}

Calle, Andres ^{[1
]}

机构：

[1] Cent Univ Ecuador, Biomed Ctr, Expt Pharmacol & Cellular Metab Unit, Quito, Ecuador

[2] Hosp Gineco Obstet Isidro Ayora, Quito, Ecuador

来源：

INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS | 2009年 / 105卷 / 01期

关键词：

Coenzyme Q10; Pre-eclampsia; Pregnancy; Supplementation; OXIDATIVE STRESS; ENDOTHELIAL FUNCTION; REPERFUSION INJURY; VITAMIN-C; Q(10); ANTIOXIDANTS; PLASMA; BLOOD; HEART;

D O I：

10.1016/j.ijgo.2008.11.033

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective: To assess whether Supplementation with Coenzyme Q10 (CoQ10) during pregnancy reduces the risk of pre-eclampsia. Methods: Women at increased risk of pre-eclampsia were enrolled in a randomized, double-blind, placebo-control led trial. Women were assigned to receive 200 mg of CoQ10 or placebo daily from 20 weeks of pregnancy until delivery. The primary outcome was rate of pre-eclampsia. Statistical analyses were by intention-to-treat. Results: Of the 235 women enrolled in the trial, 118 were randomized to receive CoQ10 and 117 received a placebo. A total of 197 (83.8%) women were followed-Up. The overall rate of pre-eclampsia was 20% (n=47). Thirty women (25.6%) in the placebo group developed pre-eclampsia compared with 17 women (14.4%) in the CoQ10 group, and this reduction was significant (P=0.035) (relative risk [RR] 0.56; 95% confidence interval [CI], 0.33-0.96). Conclusion: Supplementation with CoQ10 reduces the risk of developing pre-eclampsia in women at risk for the condition. (C) 2008 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.

引用

页码：43 / 45

页数：3

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