X-ray Structure Determination of Ion-Channel Crystalline Architectures Close to Bilayer Membrane-Confined Conditions

被引：5
作者：
Barboiu, Mihail [1 ]
Dumitrescu, Dan [1 ]
van der Lee, Arie [1 ]
机构：
[1] ENSCM UMII UMR CNRS5635, Inst Europeen Membranes, Adapt Supramol Nanosyst Grp, Pl Eugene Bataillon CC047, F-34095 Montpellier 5, France
来源：
CRYSTAL GROWTH & DESIGN | 2014年 / 14卷 / 06期
关键词：
HYBRID MATERIALS; NOBEL LECTURE; AMPHIPHILES; PROTEINS; MODELS; PORES;
D O I：
10.1021/cg500323r
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Experimental evidence presented in this paper shows that long-range crystalline order as observed in the macrocyclic heteroditopic receptors' single-crystal structures is preserved when embedded in the bilayer membranes. Investigations presented here showed that MCM41-type mesoporous hydrophobic hybrids can be used as biomimetic platforms for ion-channel biomimetic structure elucidation, while showing similar hydrophobic interactions with confined ligands/receptors as in bilayer membranes. This gives access to information concerning the structural pictures of the bilayer's confined ion-channel structures, as well as of their relatives in the presence of ion effectors.
引用
收藏
页码：3062 / 3068
页数：7
相关论文
共 36 条
  • [21] Integral Membrane Proteins in Nanodiscs Can Be Studied by Solution NMR Spectroscopy
    Glueck, Julian M.
    Wittlich, Marc
    Feuerstein, Sophie
    Hoffmann, Silke
    Willbold, Dieter
    Koenig, Bernd W.
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2009, 131 (34) : 12060 - +
  • [22] Synthetic models of cation-conducting channels
    Gokel, GW
    Mukhopadhyay, A
    [J]. CHEMICAL SOCIETY REVIEWS, 2001, 30 (05) : 274 - 286
  • [23] Artificial ion channels showing rectified current behavior
    Goto, C
    Yamamura, M
    Satake, A
    Kobuke, Y
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001, 123 (49) : 12152 - 12159
  • [24] Silica-based mesoporous organic-inorganic hybrid materials
    Hoffmann, Frank
    Cornelius, Maximilian
    Morell, Jurgen
    Froeba, Michael
    [J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2006, 45 (20) : 3216 - 3251
  • [25] Crystallization under nanoscale confinement
    Jiang, Qi
    Ward, Michael D.
    [J]. CHEMICAL SOCIETY REVIEWS, 2014, 43 (07) : 2066 - 2079
  • [26] Synthetic ion channel based on metal-organic polyhedra
    Jung, Minseon
    Kim, Hyunuk
    Baek, Kangkyun
    Kim, Kimoon
    [J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2008, 47 (31) : 5755 - 5757
  • [27] A Synthetic Ion Channel Derived from a Metallogallarene Capsule That Functions in Phospholipid Bilayers
    Kulikov, Oleg V.
    Li, Ruiqiong
    Gokel, George W.
    [J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2009, 48 (02) : 375 - 377
  • [28] Li C.J., 2005, CHEM REV, V105, P3095, DOI DOI 10.1021/CR030009U
  • [29] Potassium channels and the atomic basis of selective ion conduction (Nobel lecture)
    MacKinnon, R
    [J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2004, 43 (33) : 4265 - 4277
  • [30] En route to supramolecular functional plasticity:: artificial β-barrels, the barrel-stave motif, and related approaches
    Matile, S
    [J]. CHEMICAL SOCIETY REVIEWS, 2001, 30 (03) : 158 - 167
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