X-ray Structure Determination of Ion-Channel Crystalline Architectures Close to Bilayer Membrane-Confined Conditions

被引：5
作者：
Barboiu, Mihail [1 ]
Dumitrescu, Dan [1 ]
van der Lee, Arie [1 ]
机构：
[1] ENSCM UMII UMR CNRS5635, Inst Europeen Membranes, Adapt Supramol Nanosyst Grp, Pl Eugene Bataillon CC047, F-34095 Montpellier 5, France
来源：
CRYSTAL GROWTH & DESIGN | 2014年 / 14卷 / 06期
关键词：
HYBRID MATERIALS; NOBEL LECTURE; AMPHIPHILES; PROTEINS; MODELS; PORES;
D O I：
10.1021/cg500323r
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Experimental evidence presented in this paper shows that long-range crystalline order as observed in the macrocyclic heteroditopic receptors' single-crystal structures is preserved when embedded in the bilayer membranes. Investigations presented here showed that MCM41-type mesoporous hydrophobic hybrids can be used as biomimetic platforms for ion-channel biomimetic structure elucidation, while showing similar hydrophobic interactions with confined ligands/receptors as in bilayer membranes. This gives access to information concerning the structural pictures of the bilayer's confined ion-channel structures, as well as of their relatives in the presence of ion effectors.
引用
收藏
页码：3062 / 3068
页数：7
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