Decrease in circulating myeloid dendritic cell precursors in patients with intracranial large artery atherosclerosis

被引：0
|
作者：
Zhang, Jin-Xia [1 ]
Li, Bing-Ling [2 ]
Lin, Zhong-Qiu [3 ]
Zhang, Ni [1 ]
Peng, Xiong [1 ]
Gong, Zhi-Hua [1 ]
Long, Liu-Cheng [1 ]
Zhou, Xuan [1 ]
Xiang, Ding-Cheng [1 ]
机构：
[1] Guangzhou Gen Hosp Guangzhou Mil Command, Dept Cardiovasc, Guangzhou 510010, Guangdong, Peoples R China
[2] Guangzhou Gen Hosp Guangzhou Mil Command, Dept Pharm, Guangzhou 510010, Guangdong, Peoples R China
[3] Guangzhou Gen Hosp Guangzhou Mil Command, Dept Elderly Cardiovasc, Guangzhou 510010, Guangdong, Peoples R China
来源：
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY | 2015年 / 8卷 / 09期
关键词：
Intracranial large-artery atherosclerosis (ILAA); dendritic cell (DC); coronary atherosclerosis; angiography; MONOCYTE CHEMOATTRACTANT PROTEIN-1; NORTHERN MANHATTAN STROKE; ACUTE CORONARY SYNDROMES; RUPTURE-PRONE REGIONS; CAROTID PLAQUES; CEREBRAL ATHEROSCLEROSIS; RISK-FACTORS; DISEASE; ACCUMULATION; EXPRESSION;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Intracranial large artery atherosclerosis (ILAA) is a major cause of ischemic cerebrovascular disease. The aim of this study was to investigate whether the levels of circulating dendritic cell precursors (DCP) could reflect the severity of intracranial large artery atherosclerosis (ILAA). For this purpose, a series of angiography were taken to determine the severity and extent of coronary artery and intracranial large artery stenosis, and flow cytometry were taken to determine the levels of circulating mDC precursors and pDC precursors in patients with severe intracranial large artery atherosclerosis (ILAA) (n = 101) and mild intracranial large artery atherosclerosis (ILAA) (n = 123) according to the angiography. Circulating mDC precursors were lower in patients with severe intracranial large artery atherosclerosis (ILAA) than in mild intracranial large artery atherosclerosis (ILAA) (P < 0.05), but circulating pDC precursors were not significant differences (P > 0.05). According to these data, circulating mDC precursors could predict the severity of ILAA, which also could be able to reflect the severity of ILAA.
引用
收藏
页码：11495 / 11502
页数：8
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